NDLI: Renal epithelial cells rapidly bind and internalize calcium oxalate monohydrate crystals.

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Renal epithelial cells rapidly bind and internalize calcium oxalate monohydrate crystals.

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Renal epithelial cells rapidly bind and internalize calcium oxalate monohydrate crystals.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Swift, H. Martin, T. Patterson, B. Lieske, J. C. Toback, F. G.
Description	Author Affiliation: Lieske JC ( Department of Medicine, University of Chicago, IL 60637.);
Abstract	Renal tubular fluid is supersaturated with calcium and oxalate ions, which can nucleate to form crystals of calcium oxalate monohydrate (COM), the most abundant constituent of kidney stones. However, the mechanisms by which nascent crystals are retained in the nephron and then grow into kidney stones are unclear. An interaction of COM crystals with the surface of renal epithelial cells could be a critical initiating event in nephrolithiasis. To investigate this possibility we used cultures of monkey kidney epithelial cells (BSC-1 line) as a model system and found that [14C]COM crystals bound to the cell surface within seconds. Scanning electron microscopy revealed that crystals bind first to apical microvilli, which subsequently migrate over the crystalline surface. When visualized by transmission electron microscopy, intracellular crystals were located within vesicles. Cytoskeletal responses to crystal uptake were sought by immunofluorescence microscopy, which revealed concentration of F-actin at sites of crystal contact as well as a generalized reorganization of the intermediate filament network containing cytokeratin 8. Uptake of COM crystals did not adversely affect renal epithelial cell growth, and internalized crystals were apparently distributed to daughter cells during division. Rapid adherence of COM crystals to the apical surface of tubular epithelial cells could promote crystal retention in the kidney. Elucidation of factors that regulate this process may provide insight into the pathogenesis of nephrolithiasis.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Calcium Oxalate Metabolism Kidney Animals Cell Line Cercopithecus Aethiops Crystallization Epithelium Ultrastructure Fluorescent Antibody Technique Kidney Calculi Etiology Microscopy, Electron, Scanning Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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