NDLI: Atypical regions in large genomic DNA sequences.

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Impact melting of frozen oceans on the early Earth: Implications for the origin of life

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Atypical regions in large genomic DNA sequences.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Mcpeek, M. S. Speed, T. P. Scherer, S.
Description	Author Affiliation: Scherer S ( Human Genome Center, Lawrence Berkeley Laboratory, Berkeley, CA 94720.);
Abstract	Large genomic DNA sequences contain regions with distinctive patterns of sequence organization. We describe a method using logarithms of probabilities based on seventh-order Markov chains to rapidly identify genomic sequences that do not resemble models of genome organization built from compilations of octanucleotide usage. Data bases have been constructed from Escherichia coli and Saccharomyces cerevisiae DNA sequences of > 1000 nt and human sequences of > 10,000 nt. Atypical genes and clusters of genes have been located in bacteriophage, yeast, and primate DNA sequences. We consider criteria for statistical significance of the results, offer possible explanations for the observed variation in genome organization, and give additional applications of these methods in DNA sequence analysis.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	15
Volume Number	91
Language	English
Publisher	National Academy of Sciences
Publisher Date	1994-08-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	DNA Genetics Sequence Analysis, DNA Bacteriophage Lambda Genetic Variation Globins Information Systems Markov Chains Saccharomyces Research Support, U.S. Gov't, Non-P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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