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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sakai, Y. Kinloch, R. A. Litscher, E. S. Stewart, C. L. Wassarman, P. M. Liu, C. Mortillo, S. |
| Description | Author Affiliation: Liu C ( Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110, USA.); |
| Abstract | Mammalian eggs are surrounded by a thick extracellular coat, the zona pellucida, that plays important roles during early development. The mouse egg zona pellucida is constructed of three glycoproteins, called mZP1, mZP2, and mZP3. The gene encoding mZP3 is expressed only by growing oocytes during a 2- to 3-week period of oogenesis. Here, the mZP3 gene was disrupted by targeted mutagenesis using homologous recombination in mouse embryonic stem cells. Viable female mice homozygous for the mutated mZP3 allele (mZP3-/-) were obtained. These mice are indistinguishable in appearance from wild-type (mZP3+/+) and heterozygous (mZP3+/-) littermates. However, although ovaries of juvenile and adult mZP3-/- females possess growing and fully grown oocytes, the oocytes completely lack a zona pellucida. Consistent with this observation, eggs recovered from oviducts of superovulated, adult mZP3-/- females also lack a zona pellucida. Thus far, mZP3-/- females mated with wild-type males have failed to become pregnant. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 11 |
| Volume Number | 93 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1996-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Egg Proteins Pharmacology Infertility, Female Physiopathology Membrane Glycoproteins Oocytes Physiology Receptors, Cell Surface Zona Pellucida Animals DNA Primers Genetics Gene Expression Heterozygote Homozygote Mice Microscopy, Electron Molecular Sequence Data Mutagenesis Ultrastructure Oogenesis Ovarian Follicle Ovary Polymerase Chain Reaction Pregnancy Recombination, Genetic Stem Cells Superovulation Transfection Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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