NDLI: An upstream region of the mouse ZP3 gene directs expression of firefly luciferase specifically to growing oocytes in transgenic mice.

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An upstream region of the mouse ZP3 gene directs expression of firefly luciferase specifically to growing oocytes in transgenic mice.

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An upstream region of the mouse ZP3 gene directs expression of firefly luciferase specifically to growing oocytes in transgenic mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wassarman, P. M. Kinloch, R. A. Lira, S. A. Mortillo, S.
Description	Author Affiliation: Lira SA ( Department of Cell and Developmental Biology, Roche Research Center, Nutley, NJ 07110.);
Abstract	The gene encoding the mouse egg primary receptor for sperm, a zona pellucida glycoprotein called ZP3, is expressed exclusively in growing oocytes within ovaries of sexually immature and mature female mice. We have constructed a transgene in which 6.5 kilobases of ZP3 gene 5'-flanking sequence is fused to the coding region of the firefly luciferase gene, and we have generated four independent lines of transgenic mice. In these animals, the transgene is expressed exclusively in ovaries. Furthermore, within ovaries, expression is confined to growing oocytes, and luciferase activity can be detected by assaying individual, isolated oocytes. The pattern of firefly luciferase expression during oocyte growth is similar to that observed in previous studies of ZP3 expression during oogenesis in mice. Observations reported here strongly suggest that cis-acting elements present in the ZP3 gene 5'-flanking region regulate oocyte-specific and, therefore, sex-specific expression of the sperm receptor gene during mouse development. They also suggest that such elements can be used to direct expression of cloned genes specifically to oocytes of transgenic mice and to evaluate the effects of such expression on various aspects of early mammalian development.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	18
Volume Number	87
Language	English
Publisher	National Academy of Sciences
Publisher Date	1990-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Egg Proteins Gene Expression Genes Glycoproteins Genetics Luciferases Membrane Glycoproteins Oocytes Physiology Ovum Metabolism Promoter Regions, Genetic Receptors, Cell Surface Zona Pellucida Animals Mice Mice, Transgenic Molecular Sequence Data Nucleic Acid Hybridization Oligonucleotide Probes Enzymology Organ Specificity Ovary Plasmids Polymerase Chain Reaction RNA, Messenger Restriction Mapping Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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