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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Schlaggar, B. L. O'leary, D. D. Fox, K. Glazewski, S. |
| Description | Author Affiliation: Fox K ( Department of Physiology, University of Minnesota, Minneapolis 55455, USA.); |
| Abstract | The segregation of thalamocortical inputs into eye-specific stripes in the developing cat or monkey visual cortex is prevented by manipulations that perturb or abolish neural activity in the visual pathway. Such findings show that proper development of the functional organization of visual cortex is dependent on normal patterns of neural activity. The generalisation of this conclusion to other sensory cortices has been questioned by findings that the segregation of thalamocortical afferents into a somatotopic barrel pattern in developing rodent primary somatosensory cortex (S1) is not prevented by activity blockade. We show that a temporary block of N-methyl-D-aspartate (NMDA) and non-NMDA glutamate receptors in rat S1 during the critical period for barrel development disrupts the topographic refinement of thalamocortical connectivity and columnar organization. These effects are evident well after the blockade is ineffective and thus may be permanent. Our findings show that neural activity and specifically the activation of postsynaptic cortical neurons has a prominent role in establishing the primary sensory map in S1, as well as the topographic organization of higher order synaptic connections. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 11 |
| Volume Number | 93 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 1996-07-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | 2-Amino-5-phosphonovalerate Pharmacology Cerebral Cortex Physiology Excitatory Amino Acid Antagonists Neurons Receptors, Glutamate Somatosensory Cortex Growth & Development Synapses Thalamus Visual Cortex Metabolism Afferent Pathways Drug Effects Aging Animals Animals, Newborn Cytology Haplorhini Rats, Sprague-Dawley Reference Values Vibrissae Comparative Study Research Support, U.S. Gov't, P.H.S. Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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