NDLI: The small GTPase RalA targets filamin to induce filopodia.

Please wait, while we are loading the content...

Year: 2017 Volume: 114

Year: 2016 Volume: 113

Year: 2015 Volume: 112

Year: 2014 Volume: 111

Year: 2013 Volume: 110

Year: 2012 Volume: 109

Year: 2011 Volume: 108

Year: 2010 Volume: 107

Year: 2009 Volume: 106

Year: 2008 Volume: 105

Year: 2007 Volume: 104

Year: 2006 Volume: 103

Year: 2005 Volume: 102

Year: 2004 Volume: 101

Year: 2003 Volume: 100

Year: 2002 Volume: 99

Year: 2001 Volume: 98

Year: 2000 Volume: 97

Year: 1999 Volume: 96

Year: 1999 Volume: 96 Issue: 26

Year: 1999 Volume: 96 Issue: 25

Year: 1999 Volume: 96 Issue: 24

Year: 1999 Volume: 96 Issue: 23

Year: 1999 Volume: 96 Issue: 22

Year: 1999 Volume: 96 Issue: 21

Year: 1999 Volume: 96 Issue: 20

Year: 1999 Volume: 96 Issue: 19

Year: 1999 Volume: 96 Issue: 18

Year: 1999 Volume: 96 Issue: 17

Year: 1999 Volume: 96 Issue: 16

Year: 1999 Volume: 96 Issue: 15

Year: 1999 Volume: 96 Issue: 14

Year: 1999 Volume: 96 Issue: 13

Year: 1999 Volume: 96 Issue: 12

Year: 1999 Volume: 96 Issue: 11

Year: 1999 Volume: 96 Issue: 10

Year: 1999 Volume: 96 Issue: 9

Year: 1999 Volume: 96 Issue: 8

Year: 1999 Volume: 96 Issue: 7

Year: 1999 Volume: 96 Issue: 6

Year: 1999 Volume: 96 Issue: 5

Phenylketonuria: old disease, new approach to treatment.

What sets the TonE during osmotic stress?

Mitochondria and dystonia: the movement disorder connection?

Engineering of bacterial ribosomes: replacement of all seven Escherichia coli rRNA operons by a single plasmid-encoded operon.

DNA secondary structure: a common and causative factor for expansion in human disease.

Borrowing to make ends meet.

Tight frames of k-plane ridgelets and the problem of representing objects that are smooth away from d-dimensional singularities in Rn.

Nonlinear indicial response of complex nonstationary oscillations as pulmonary hypertension responding to step hypoxia.

Overexpression of the Bacillus thuringiensis (Bt) Cry2Aa2 protein in chloroplasts confers resistance to plants against susceptible and Bt-resistant insects.

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel 'unnatural' natural products.

Unexpected crucial role of residue 225 in serine proteases.

Proteasome-dependent degradation of the human estrogen receptor.

Structure of a cytochrome P450-redox partner electron-transfer complex.

Studies on the interactions between human replication factor C and human proliferating cell nuclear antigen.

p53-induced DNA bending and twisting: p53 tetramer binds on the outer side of a DNA loop and increases DNA twisting.

Interaction of 5-lipoxygenase with cellular proteins.

tRNAVal-heterodimeric maxizymes with high potential as geneinactivating agents: simultaneous cleavage at two sites in HIV-1 Tat mRNA in cultured cells.

Fibroblast growth factors 1 and 2 are distinct in oligomerization in the presence of heparin-like glycosaminoglycans.

Small antibody-like proteins with prescribed ligand specificities derived from the lipocalin fold.

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.

Selenium redox biochemistry of zinc-sulfur coordination sites in proteins and enzymes.

Native display of complete foreign protein domains on the surface of hepatitis B virus capsids.

Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage.

Structure and function in rhodopsin: kinetic studies of retinal binding to purified opsin mutants in defined phospholipid-detergent mixtures serve as probes of the retinal binding pocket.

Structure and function in rhodopsin: further elucidation of the role of the intradiscal cysteines, Cys-110, -185, and -187, in rhodopsin folding and function.

Inhibitory sites in enzymes: zinc removal and reactivation by thionein.

Mg-chelatase of tobacco: the role of the subunit CHL D in the chelation step of protoporphyrin IX.

The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit.

Affinity modulation of small-molecule ligands by borrowing endogenous protein surfaces

Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID

The crayfish plasma clotting protein: a vitellogenin-related protein responsible for clot formation in crustacean blood.

An Escherichia coli strain with all chromosomal rRNA operons inactivated: complete exchange of rRNA genes between bacteria.

Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas.

Tolerance of Arc repressor to multiple-alanine substitutions.

Direct interaction of lignin and lignin peroxidase from Phanerochaete chrysosporium.

Ligand-dependent activation of transcription in vitro by retinoic acid receptor alpha/retinoid X receptor alpha heterodimers that mimics transactivation by retinoids in vivo.

The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH.

Specificity of native-like interhelical hydrophobic contacts in the apomyoglobin intermediate.

Cryptocyanin, a crustacean molting protein: evolutionary link with arthropod hemocyanins and insect hexamerins.

A specific transition state for S-peptide combining with folded S-protein and then refolding.

Energy-based de novo protein folding by conformational space annealing and an off-lattice united-residue force field: application to the 10-55 fragment of staphylococcal protein A and to apo calbindin D9K.

Stretching lattice models of protein folding.

The two-dimensional IR nonlinear spectroscopy of a cyclic penta-peptide in relation to its three-dimensional structure.

Copper binding to the prion protein: structural implications of four identical cooperative binding sites.

Protrusive growth from giant liposomes driven by actin polymerization.

Multiple pathways for ultrafast transduction of light energy in the photosynthetic reaction center of Rhodobacter sphaeroides

Mouse trp2, the homologue of the human trpc2 pseudogene, encodes mTrp2, a store depletion-activated capacitative $Ca^{2+}$ entry channel

Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization.

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B.

Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids.

Adhesion to fibronectin stimulates proliferation of wild-type and bcr/abl-transfected murine hematopoietic cells.

The cellular ecology of progressive neoplastic transformation: a clonal analysis.

Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease.

Immunophilins, Refsum disease, and lupus nephritis: The peroxisomal enzyme phytanoyl-COA α-hydroxylase is a new FKBP-associated protein

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.

Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly.

The small GTPase RalA targets filamin to induce filopodia.

The RD114/simian type D retrovirus receptor is a neutral amino acid transporter.

Dynamic and quantitative $Ca^{2+}$ measurements using improved cameleons

Human deafness dystonia syndrome is a mitochondrial disease.

p53 regulates a $G_{2}$ checkpoint through cyclin B1

Dynamics and elasticity of the fibronectin matrix in living cell culture visualized by fibronectin-green fluorescent protein.

In vitro hematopoietic and endothelial potential of flk-1(-/-) embryonic stem cells and embryos.

Conservation of the expression and function of apterous orthologs in Drosophila and mammals.

Spontaneous heterosis in larval life-history traits of hemiclonal frog hybrids

Molecular studies suggest that cartilaginous fishes have a terminal position in the piscine tree.

Expression of a Hox gene, Cnox-2, and the division of labor in a colonial hydroid.

Coalescent estimates of HIV-1 generation time in vivo.

Evolutionary relationships among diverse bacteriophages and prophages: all the world's a phage.

Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.

Yeast and human genes that affect the Escherichia coli SOS response.

Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice

Conformational changes in tertiary structure near the ligand binding site of an integrin I domain.

In situ detection of activated Bruton’s tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies

Terreic acid, a quinone epoxide inhibitor of Bruton's tyrosine kinase.

Immune surveillance against a solid tumor fails because of immunological ignorance.

Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras.

Efficient IgG-mediated suppression of primary antibody responses in Fcgamma receptor-deficient mice.

Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system.

Gene expression, synthesis, and secretion of interleukin 18 and interleukin 1beta are differentially regulated in human blood mononuclear cells and mouse spleen cells.

Predominant VH genes expressed in innate antibodies are associated with distinctive antigen-binding sites.

Systemic administration of interleukin 2 enhances the therapeutic efficacy of dendritic cell-based tumor vaccines.

Dopamine beta-hydroxylase deficiency impairs cellular immunity.

Crossreactive recognition of viral, self, and bacterial peptide ligands by human class I-restricted cytotoxic T lymphocyte clonotypes: implications for molecular mimicry in autoimmune disease.

Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides.

In vivo analysis of the 3' untranslated region of the hepatitis C virus after in vitro mutagenesis of an infectious cDNA clone.

Neonatal gene transfer leads to widespread correction of pathology in a murine model of lysosomal storage disease.

Poly(ADP-ribose) polymerase gene disruption conferred mice resistant to streptozotocin-induced diabetes.

Mutations in the nebulin gene associated with autosomal recessive nemaline myopathy.

Blood-borne tissue factor: another view of thrombosis.

Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.

Analysis of masked mutations in familial adenomatous polyposis.

Regulation of fatty acid homeostasis in cells: novel role of leptin.

Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography.

A different approach to treatment of phenylketonuria: phenylalanine degradation with recombinant phenylalanine ammonia lyase.

Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat.

Ex vivo evaluation of a Taylor-Couette flow, immobilized heparinase I device for clinical application.

Mutations in the organic cation/carnitine transporter OCTN2 in primary carnitine deficiency.

Gonadotropin-releasing hormone analogue conjugates with strong selective antitumor activity

Interferon gamma expressed by a recombinant respiratory syncytial virus attenuates virus replication in mice without compromising immunogenicity.

Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles.

Streptavidin facilitates internalization and pulmonary targeting of an anti-endothelial cell antibody (platelet-endothelial cell adhesion molecule 1): a strategy for vascular immunotargeting of drugs.

Inhibition of advanced glycation endproduct formation by acetaldehyde: role in the cardioprotective effect of ethanol.

Reversing adipocyte differentiation: implications for treatment of obesity.

The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1.

Continuous axenic cultivation of Pneumocystis carinii.

Pseudomonas aeruginosa killing of Caenorhabditis elegans used to identify P. aeruginosa virulence factors.

Preferential $Zn^{2+}$ influx through $Ca^{2+}-permeable$ AMPA/kainate channels triggers prolonged mitochondrial superoxide production

A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins.

The biological clock of very premature primate infants is responsive to light.

Retinotopic mapping of lateral geniculate nucleus in humans using functional magnetic resonance imaging.

$Ca^{2+}-induced$ inhibition of the cardiac $Ca^{2+}$ channel depends on calmodulin

Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly.

Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury.

Overexpression of a Shaker-type potassium channel in mammalian central nervous system dysregulates native potassium channel gene expression

Dopamine receptor subtypes modulate olfactory bulb gamma-aminobutyric acid type A receptors.

Growth factor-mediated Fyn signaling regulates alpha-amino-3- hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor expression in rodent neocortical neurons.

Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells.

Autoinhibition of serotonin cells: an intrinsic regulatory mechanism sensitive to the pattern of usage of the cells.

A neomorphic syntaxin mutation blocks volatile-anesthetic action in Caenorhabditis elegans.

Blockade of N-methyl-D-aspartate receptor activation suppresses learning-induced synaptic elimination.

Cloning, expression, and genetic mapping of Sema W, a member of the semaphorin family

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins.

N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain.

Epithelial sodium channel regulated by aldosterone-induced protein sgk

Hormonal prevention of breast cancer: mimicking the protective effect of pregnancy.

Two gonadotropin-releasing hormone receptor subtypes with distinct ligand selectivity and differential distribution in brain and pituitary in the goldfish (Carassius auratus).

Correlation of regional cerebral blood flow and change of plasma sodium concentration during genesis and satiation of thirst.

Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity.

Modulation of the baboon (Papio anubis) uterine endometrium by chorionic gonadotrophin during the period of uterine receptivity.

Expression of alfalfa mosaic virus coat protein in tobacco mosaic virus (TMV) deficient in the production of its native coat protein supports long-distance movement of a chimeric TMV.

Male gametic cell-specific gene expression in flowering plants.

Canine sexual dimorphism in Egyptian Eocene anthropoid primates: Catopithecus and Proteopithecus.

Prehistoric birds from New Ireland, Papua New Guinea: extinctions on a large Melanesian island.

Year: 1999 Volume: 96 Issue: 4

Year: 1999 Volume: 96 Issue: 3

Year: 1999 Volume: 96 Issue: 2

Year: 1999 Volume: 96 Issue: 1

Year: 1998 Volume: 95

Year: 1997 Volume: 94

Year: 1996 Volume: 93

Year: 1995 Volume: 92

Year: 1994 Volume: 91

Year: 1993 Volume: 90

Year: 1992 Volume: 89

Year: 1991 Volume: 88

Year: 1990 Volume: 87

Year: 1989 Volume: 86

Year: 1988 Volume: 85

Year: 1987 Volume: 84

Year: 1986 Volume: 83

Year: 1985 Volume: 82

Year: 1984 Volume: 81

Year: 1983 Volume: 80

Year: 1982 Volume: 79

Year: 1981 Volume: 78

Year: 1980 Volume: 77

Year: 1979 Volume: 76

Year: 1978 Volume: 75

Year: 1977 Volume: 74

Year: 1976 Volume: 73

Year: 1975 Volume: 72

Year: 1974 Volume: 71

Year: 1973 Volume: 70

Year: 1972 Volume: 69

Year: 1971 Volume: 68

Year: 1970 Volume: 67

Year: 1970 Volume: 66

Year: 1970 Volume: 65

Year: 1969 Volume: 64

Year: 1969 Volume: 63

Year: 1969 Volume: 62

Year: 1968 Volume: 61

Year: 1968 Volume: 60

Year: 1968 Volume: 59

Year: 1967 Volume: 58

Year: 1967 Volume: 57

Year: 1966 Volume: 56

Year: 1966 Volume: 55

The small GTPase RalA targets filamin to induce filopodia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nakamura, S. Hartwig, J. H. Stossel, T. P. Ohta, Y. Suzuki, N.
Description	Author Affiliation: Ohta Y ( Division of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187, Japan. ohta@ncnaxp.ncnp.go.jp);
Abstract	The Ras-related small GTPases Rac, Rho, Cdc42, and RalA bind filamin, an actin filament-crosslinking protein that also links membrane and other intracellular proteins to actin. Of these GTPases only RalA binds filamin in a GTP-specific manner, and GTP-RalA elicits actin-rich filopods on surfaces of Swiss 3T3 cells and recruits filamin into the filopodial cytoskeleton. Either a dominant negative RalA construct or the RalA-binding domain of filamin 1 specifically block Cdc42-induced filopod formation, but a Cdc42 inhibitor does not impair RalA's effects, which, unlike Cdc42, are Rac independent. RalA does not generate filopodia in filamin-deficient human melanoma cells, whereas transfection of filamin 1 restores the functional response. RalA therefore is a downstream intermediate in Cdc42-mediated filopod production and uses filamin in this pathway.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	96
Language	English
Publisher	National Academy of Sciences
Publisher Date	1999-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Contractile Proteins Metabolism GTP Phosphohydrolases Microfilament Proteins Pseudopodia Physiology Ral GTP-Binding Proteins 3T3 Cells Actins Animals COS Cells Carrier Proteins Cloning, Molecular Cytoskeleton Ultrastructure Escherichia Coli Filamins Genetics Kinetics Membrane Proteins Mice Microscopy, Video Recombinant Fusion Proteins Biosynthesis Recombinant Proteins Time Factors Transfection Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in