NDLI: Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids.

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Interferon-induced human MxA GTPase blocks nuclear import of Thogoto virus nucleocapsids.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kochs, G. Haller, O.
Description	Author Affiliation: Kochs G ( Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, D-79008 Freiburg, Germany.);
Abstract	Interferon-induced human MxA protein belongs to the dynamin superfamily of large GTPases. It exhibits antiviral activity against a variety of RNA viruses, including Thogoto virus, an influenza virus-like orthomyxovirus transmitted by ticks. Here, we report that MxA blocks the transport of Thogoto virus nucleocapsids into the nucleus, thereby preventing transcription of the viral genome. This interaction can be abolished by a mAb that neutralizes the antiviral activity of MxA. Our results reveal an antiviral mechanism whereby an interferon-induced protein traps the incoming virus and interferes with proper transport of the viral genome to its ultimate target compartment within the infected cell.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	96
Language	English
Publisher	National Academy of Sciences
Publisher Date	1999-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Cell Nucleus Physiology Virology GTP Phosphohydrolases Metabolism GTP-Binding Proteins Interferons Pharmacology Nucleocapsid Proteins Proteins Thogotovirus 3T3 Cells Animals Antibodies, Monoclonal Antiviral Agents Cell Line Cricetinae Cycloheximide Enzyme Induction Genome, Viral Mice Models, Biological Myxovirus Resistance Proteins Genetics Protein Biosynthesis Transcription, Genetic Virus Replication Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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