NDLI: Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles.

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Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Lowy, D. R. Schiller, J. T. Chackerian, B.
Description	Author Affiliation: Chackerian B ( Laboratory of Cellular Oncology, National Institutes of Health, Building 36, Room 1D-32, Bethesda, MD 20892-4040, USA.);
Abstract	The vertebrate immune system has evolved to respond vigorously to microbial infection but to ignore self-antigens. Evidence has emerged that B cell responses to viruses are initiated by immune recognition of ordered arrays of antigen on the viral surface. To test whether autoantibodies against a self-antigen can be induced by placing it in a context that mimics the ordered surface of a viral particle, a peptide representing an extracellular loop of the mouse chemokine receptor CCR5 was incorporated into an immunodominant site of the bovine papillomavirus virus L1 coat protein, which self-assembles into virus-like particles. Mice inoculated with chimeric L1-CCR5 particles generated autoantibodies that bound to native mouse CCR5, inhibited binding of its ligand RANTES, and blocked HIV-1 infection of an indicator cell line expressing a human-mouse CCR5 chimera. These results suggest a general method for inducing autoantibodies against self-antigens, with diverse potential basic research and clinical applications.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	96
Language	English
Publisher	National Academy of Sciences
Publisher Date	1999-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Autoantibodies Blood Autoantigens Immunology Immunoglobulin G Receptors, CCR5 Animals Antibody Formation Bovine Papillomavirus 1 Genetics Capsid Enzyme-Linked Immunosorbent Assay HeLa Cells Mice Mice, Inbred C57BL Chemistry Recombinant Fusion Proteins Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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