NDLI: Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.

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Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Eldridge, W. Boehnke, M. Segal, L. Ghosh, S. Collins, F. S. Birznieks, G. Vidgren, G. Shurtleff, B. Balow, J. Erdos, M. R. Kaleta, H. S. Tenkula, T. Watanabe, R. M. Eriksson, J. Tuomilehto, J. Valle, T. Kudelko, K. Bergman, R. N. Chang, J. Magnuson, V. L. Musick, A. Ehnholm, C. Blaschak-harvan, J. Buchanan, T. A. Hagopian, W. Shapiro, S. Te, C. Kohtamaki, K. Witt, A. So, A. Porter, R. Tannenbaum, J. Langefeld, C. D. Sharaf, R. Martin, C. Unni, A. Hauser, E. R. Chines, P. Tuomilehto-wolf, E. Ally, D. S.
Spatial Coverage	Finland
Description	Author Affiliation: Ghosh S ( Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. sghosh@alw.nih.gov);
Abstract	We are conducting a genome scan at an average resolution of 10 centimorgans (cM) for type 2 diabetes susceptibility genes in 716 affected sib pairs from 477 Finnish families. To date, our best evidence for linkage is on chromosome 20 with potentially separable peaks located on both the long and short arms. The unweighted multipoint maximum logarithm of odds score (MLS) was 3.08 on 20p (location, chi = 19.5 cM) under an additive model, whereas the weighted MLS was 2.06 on 20q (chi = 57 cM, recurrence risk,lambda(s) = 1. 25, P = 0.009). Weighted logarithm of odds scores of 2.00 (chi = 69.5 cM, P = 0.010) and 1.92 (chi = 18.5 cM, P = 0.013) were also observed. Ordered subset analyses based on sibships with extreme mean values of diabetes-related quantitative traits yielded sets of families who contributed disproportionately to the peaks. Two-hour glucose levels in offspring of diabetic individuals gave a MLS of 2. 12 (P = 0.0018) at 9.5 cM. Evidence from this and other studies suggests at least two diabetes-susceptibility genes on chromosome 20. We have also screened the gene for maturity-onset diabetes of the young 1, hepatic nuclear factor 4-a (HNF-4alpha) in 64 affected sibships with evidence for high chromosomal sharing at its location on chromosome 20q. We found no evidence that sequence changes in this gene accounted for the linkage results we observed.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	96
Language	English
Publisher	National Academy of Sciences
Publisher Date	1999-04-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Chromosomes, Human, Pair 20 Diabetes Mellitus, Type 2 Genetics Genetic Predisposition To Disease Genetic Variation Models, Genetic Phosphoproteins Transcription Factors Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Blood Glucose Metabolism Chromosome Mapping DNA-Binding Proteins Blood Exons Finland Genetic Linkage Genetic Markers Glucose Tolerance Test Hepatocyte Nuclear Factor 4 Introns Nuclear Family Odds Ratio Point Mutation Polymorphism, Single-Stranded Conformational Sequence Deletion Spouses Multicenter Study Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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