NDLI: Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I.

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Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I.

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Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Moser, T. Lund, P. E. Südhof, T. C. Neher, E. Chow, R. H. Voets, T. Geppert, M.
Description	Author Affiliation: Voets T ( Department of Membrane Biophysics, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Göttingen, Germany. Thomas.Voets@med.kuleuven.ac.be);
Abstract	Synaptotagmin I is a synaptic vesicle-associated protein essential for synchronous neurotransmission. We investigated its impact on the intracellular Ca(2+)-dependence of large dense-core vesicle (LDCV) exocytosis by combining Ca(2+)-uncaging and membrane capacitance measurements in adrenal slices from mouse synaptotagmin I null mutants. Synaptotagmin I-deficient chromaffin cells displayed prolonged exocytic delays and slow, yet Ca(2+)-dependent fusion rates, resulting in strongly reduced LDCV release in response to short depolarizations. Vesicle recruitment, the shape of individual amperometric events, and endocytosis appeared unaffected. These findings demonstrate that synaptotagmin I is required for rapid, highly Ca(2+)-sensitive LDCV exocytosis and indicate that it regulates the equilibrium between a slowly releasable and a readily releasable state of the fusion machinery. Alternatively, synaptotagmin I could function as calcium sensor for the readily releasable pool, leading to the destabilization of the pool in its absence.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Adrenal Glands Physiology Calcium-Binding Proteins Metabolism Calcium Chromaffin Cells Exocytosis Intracellular Fluid Membrane Glycoproteins Nerve Tissue Proteins Animals Animals, Newborn Deficiency In Vitro Techniques Mice Mice, Knockout Synaptotagmin I Synaptotagmins Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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