NDLI: Immunogene therapy of tumors with vaccine based on Xenopus homologous vascular endothelial growth factor as a model antigen.

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Immunogene therapy of tumors with vaccine based on Xenopus homologous vascular endothelial growth factor as a model antigen.

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Immunogene therapy of tumors with vaccine based on Xenopus homologous vascular endothelial growth factor as a model antigen.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wei, Y. Q. Hu, M. Peng, F. Li, Q. Xie, X. J. Yang, L. Zhang, W. Niu, T. Lei, S. Jiang, Y. Huang, M. J. Lou, Y. Y. Zhou, L. Q. Xiao, F. Liu, J. Y. He, Q. M. Wu, Y. Liu, F. Tian, L. Wen, Y. J. Kang, B. Lu, Y. Mao, Y. Q. Wang, Q. R. Zhao, X. Zhou, H. Hu, B. Lu, C. J. Shu, J. M. Luo, F. Ding, Z. Y.
Description	Author Affiliation: Wei YQ ( Center for Biotherapy of Cancer and Cancer Research Center, First University Hospital, HuaXi Medical School, Sichuan University, Guo Xue Xiang, People's Republic of China. yuquawei@mail.sc.cninfo.net);
Abstract	Overcoming immune tolerance of the growth factors associated with tumor growth should be a useful approach to cancer therapy by active immunity. We used vascular endothelial growth factor (VEGF) as a model antigen to explore the feasibility of the immunogene tumor therapy with a vaccine based on a single xenogeneic homologous gene, targeting the growth factors associated with angiogenesis. To test this concept, we constructed a plasmid DNA encoding Xenopus homologous VEGF (XVEGF-p) and control vectors. We found that immunogene tumor therapy with a vaccine based on XVEGF was effective at both protective and therapeutic antitumor immunity in several tumor models in mice. VEGF-specific autoantibodies in sera of mice immunized with XVEGF-p could be found in Western blotting analysis and ELISA assay. The purified immunoglobulins were effective at the inhibition of VEGF-mediated endothelial cell proliferation in vitro, and at antitumor activity and the inhibition of angiogenesis by adoptive transfer in vivo. The elevation of VEGF in the sera of the tumor-bearing mice could be abrogated with XVEGF-p immunization. The antitumor activity and production of VEGF-specific autoantibodies, significantly elevated IgG1 and IgG2b, could be abrogated by the depletion of CD4(+) T lymphocytes. The observations may provide a vaccine strategy for cancer therapy through the induction of autoimmunity against the growth factors associated with tumor growth in a cross reaction with single xenogeneic homologous gene and may be of importance in the further exploration of the applications of other xenogeneic homologous genes identified in human and other animal genome sequence projects in cancer therapy.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	20
Volume Number	98
Language	English
Publisher	National Academy of Sciences
Publisher Date	2001-09-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Endothelial Growth Factors Immunology Lymphocyte Subsets Lymphokines Animals Antibodies, Monoclonal Genetics Enzyme-Linked Immunosorbent Assay Fibrosarcoma Gene Library Immunohistochemistry Immunotherapy Killer Cells, Natural Liver Neoplasms, Experimental Lymphocyte Depletion Mammary Neoplasms, Experimental Mice Models, Immunological T-Lymphocytes Tumor Cells, Cultured Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Xenopus Laevis Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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