NDLI: Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells.

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Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells.

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Ligand binding to somatostatin receptors induces receptor-specific oligomer formation in live cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Patel, Yogesh C. Hazlett, Theodore Gratton, Enrico Eid, John S. Rani, Aruna Kumar, Ujendra Grant, Michael Rocheville, Magalie Lamb, Don C. Patel, Shutish C. Patel, Ramesh C.
Description	Author Affiliation: Patel RC ( Fraser Laboratories, Department of Medicine, McGill University, and Royal Victoria Hospital, Montreal, QC, Canada H3A 1A1.);
Abstract	Heptahelical receptors (HHRs) are generally thought to function as monomeric entities. Several HHRs such as somatostatin receptors (SSTRs), however, form homo- and heterooligomers when activated by ligand binding. By using dual fluorescent ligands simultaneously applied to live cells monotransfected with SSTR5 (R5) or SSTR1 (R1), or cotransfected with R5 and R1, we have analyzed the ligand receptor stoichiometry and aggregation states for the three receptor systems by fluorescence resonance energy transfer and fluorescence correlation spectroscopy. Both homo- and heterooligomeric receptors are occupied by two ligand molecules. We find that monomeric, homooligomeric, and heterooligomeric receptor species occur in the same cell cotransfected with two SSTRs, and that oligomerization of SSTRs is regulated by ligand binding by a selective process that is restricted to some (R5) but not other (R1) SSTR subtypes. We propose that induction by ligand of different oligomeric states of SSTRs represents a unique mechanism for generating signaling specificity not only within the SSTR family but more generally in the HHR family.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Receptors, Somatostatin Metabolism Animals CHO Cells Cricetinae Fluorescent Dyes Ligands Oligopeptides Protein Binding Genetics Spectrometry, Fluorescence Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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