NDLI: Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin.

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Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin.

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Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Winter, Harald Weber, Thomas Rohbock, Karin Mack, Andreas Zimmermann, Ulrike Zenner, Hans-peter Köpschall, Iris Knipper, Marlies
Description	Author Affiliation: Weber T ( Department of Otolaryngology, Laboratory of Molecular Neurobiology, University of Tübingen, Röntgenweg 11, 72076 Tübingen, Germany.);
Abstract	The most impressive property of outer hair cells (OHCs) is their ability to change their length at high acoustic frequencies, thus providing the exquisite sensitivity and frequency-resolving capacity of the mammalian hearing organ. Prestin, a protein related to a sulfate/anion transport protein, recently has been identified and proposed as the OHC motor molecule. Homology searches of 1.5 kb of genomic DNA 5' of the coding region of the prestin gene allowed the identification of a thyroid hormone (TH) response element (TRE) in the first intron upstream of the prestin ATG codon. Prestin(TRE) bound TH receptors as a monomer or presumptive heterodimer and mediated a triiodothyronine-dependent transactivation of a heterologous promotor in response to triiodothyronine receptors alpha and beta. Retinoid X receptor-alpha had an additive effect. Expression of prestin mRNA and prestin protein was reduced strongly in the absence of TH. Although prestin protein typically was redistributed to the lateral membrane before the onset of hearing, an immature pattern of prestin protein distribution across the entire OHC membrane was noted in hypothyroid rats. The data suggest TH as a first transcriptional regulator of the motor protein prestin and as a direct or indirect modulator of subcellular prestin distribution.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Proteins Genetics Receptors, Thyroid Hormone Trans-Activators Metabolism Transcriptional Activation Triiodothyronine 5' Flanking Region Animals Anion Transport Proteins Cell Line Cochlea DNA, Complementary DNA-Binding Proteins Genes, Reporter Hair Cells, Auditory, Outer HeLa Cells Luciferases Molecular Sequence Data Rats, Wistar Receptors, Cytoplasmic And Nuclear Recombinant Fusion Proteins Response Elements Pharmacology Transfection Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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