NDLI: Genes, pseudogenes, and Alu sequence organization across human chromosomes 21 and 22.

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Genes, pseudogenes, and Alu sequence organization across human chromosomes 21 and 22.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Chingfer Gentles, Andrew J. Jurka, Jerzy Karlin, Samuel
Description	Author Affiliation: Chen C ( Department of Mathematics, Stanford University, Stanford, CA 94305-2125, USA.);
Abstract	Human chromosomes 21 and 22 (mainly the q-arms) were the first complete parts of the human genome released. Our analysis of genes, pseudogenes (Psig), and Alu repeats across these chromosomes include the following findings: The number of gene structures containing untranslated exons exceeds 25%; the terminal exon tends to be the largest among exons, whereas, the initial intron tends to be the largest among introns; single-exon gene length is approximately the mean gene exon number times the mean internal exon length; processed Psig lengths are on average approximately the same as single-exon gene length; and the G+C content and length of genes are uncorrelated. The counts and distribution of genes, Psig, and Alu sequences and G+C variation are evaluated with respect to clusters and overdispersions. Other assessments concern comparisons of intergenic lengths, properties of Psig sequences, and correlations between Alu and Psig sequences.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Alu Elements Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 22 Pseudogenes DNA, Intergenic Exons Genes Introns Protein Biosynthesis Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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