NDLI: An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels

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An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels

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An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Diamonti, A. John Guy, Pamela M. Ivanof, Caryn Sweeney, Colleen Wong, Karen Carraway, Kermit L.
Description	Author Affiliation: Diamonti AJ ( Department of Cell Biology, Harvard Medical School and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.);
Abstract	Despite numerous recent advances in our understanding of the molecular mechanisms underlying receptor tyrosine kinase down-regulation and degradation in response to growth factor binding, relatively little is known about ligand-independent receptor tyrosine kinase degradation mechanisms. In a screen for proteins that might regulate the trafficking or localization of the ErbB3 receptor, we have identified a tripartite or RBCC (RING, B-box, coiled-coil) protein that interacts with the cytoplasmic tail of the receptor in an activation-independent manner. We have named this protein Nrdp1 for neuregulin receptor degradation protein-1. Northern blotting reveals ubiquitous distribution of Nrdp1 in human adult tissues, but message is particularly prominent in heart, brain, and skeletal muscle. Nrdp1 interacts specifically with the neuregulin receptors ErbB3 and ErbB4 and not with epidermal growth factor receptor or ErbB2. When coexpressed in COS7 cells, Nrdp1 mediates the redistribution of ErbB3 from the cell surface to intracellular compartments and induces the suppression of ErbB3 and ErbB4 receptor levels but not epidermal growth factor receptor or ErbB2 levels. A putative dominant-negative form of Nrdp1 potentiates neuregulin-stimulated Erk1/2 activity in transfected MCF7 breast tumor cells. Our observations suggest that Nrdp1 may act to regulate steady-state cell surface neuregulin receptor levels, thereby influencing the efficiency of neuregulin signaling.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Neuregulins Metabolism Proteins Receptor, Epidermal Growth Factor Receptor, ErbB-3 Amino Acid Sequence Animals COS Cells Cell Line Cercopithecus Aethiops Molecular Sequence Data Genetics Receptor, ErbB-2 Receptor, ErbB-4 Signal Transduction Spodoptera Cytology Ubiquitin-Protein Ligases Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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