NDLI: Dynamics of bacterial phenotype selection in a colonized host.

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Dynamics of bacterial phenotype selection in a colonized host.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Webb, G. F. Blaser, M. J.
Description	Author Affiliation: Webb GF ( Department of Mathematics, Vanderbilt University, Nashville, TN 37240, USA. glenn.f.webb@vanderbilt.edu);
Abstract	The population dynamics of Helicobacter pylori during colonization in an infected animal host provide a quantifiable experimental model of in vivo microbial phenotype evolution. Phenotype variability in H. pylori populations can be typed as polymorphic expression of Lewis antigens on their cell surfaces. The high mutational frequency of H. pylori for Lewis expression provides substrate for differential selection by the host. Experimental challenge and successful colonization of mice and gerbils allows tracking of H. pylori phenotype variability from the initial inoculation to the ultimate establishment of a quasispecies. Colonization data provide a quantitative experimental model of phenotype evolution in a relatively large population (>10(4) individuals) over a relatively long evolutionary time scale (>10(3) generations). A mathematical model is developed to interpret the data in terms of the dynamic processes occurring during colonization. The mathematical model distinguishes the roles of selection and mutation; quantifies the effects of initial phenotype diversity, mutational frequency, and selective advantage; and applies generally to phenotype evolution in biological populations.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Evolution, Molecular Helicobacter Infections Microbiology Helicobacter Pylori Genetics Animals Antigens, CD15 Biosynthesis Disease Models, Animal Gerbillinae Lewis Blood-Group System Lipopolysaccharides Mathematical Computing Mice Mice, Inbred C3H Models, Biological Mutagenesis Phenotype Selection, Genetic Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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