NDLI: The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling.

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Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA.

A comparison of experimental, theoretical, and numerical simulation Rayleigh-Taylor mixing rates.

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Light modulation of Rubisco in Arabidopsis requires a capacity for redox regulation of the larger Rubisco activase isoform.

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The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling.

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The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hon, Michelle Evans, Ronald M. Shi, Yanhong
Description	Author Affiliation: Shi Y ( Howard Hughes Medical Institute, The Salk Institute for Biological Studies, Gene Expression Laboratory, La Jolla, CA 92037, USA.);
Abstract	The three PPAR (peroxisome proliferator-activated receptor) isoforms are critical regulators of lipid homeostasis by controlling the balance between the burning and storage of long chain fatty acids. Whereas PPARalpha and PPARgamma have been studied extensively, the function of PPARdelta remains the most elusive. Intriguingly, in cotransfection experiments, PPARdelta is a potent inhibitor of ligand-induced transcriptional activity of PPARalpha and PPARgamma. This inhibition is achieved, in part, by binding of PPARdelta to a peroxisome proliferator response element and the association of nonliganded PPARdelta with corepressors SMRT (silencing mediator for retinoid and thyroid hormone receptors), SHARP (SMRT and histone deacetylase-associated repressor protein), and class I histone deacetylases. Stable expression of PPARdelta inhibits the expression of endogenous PPARalpha target gene expression in 3T3-PPARalpha cells, whereas a PPARdelta mutant that does not interact with the corepressor SMRT loses its ability to repress the induction of PPARalpha target gene. Similarly, stable expression of PPARdelta in 3T3-PPARgamma cells leads to inhibition of PPARgamma target gene expression and PPARgamma-mediated adipogenesis. Given the widespread expression of PPARdelta and the restricted pattern for PPARalpha and PPARgamma, these results suggest a role for PPARdelta as a gateway receptor whose relative levels of expression can be used to modulate PPARalpha and PPARgamma activity.
ISSN	00278424
e-ISSN	10916490
Journal	Proceedings of the National Academy of Sciences of the United States of America
Issue Number	5
Volume Number	99
Language	English
Publisher	National Academy of Sciences
Publisher Date	2002-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Receptors, Cytoplasmic And Nuclear Metabolism Repressor Proteins Signal Transduction Transcription Factors Transcription, Genetic 3T3 Cells Animals Cell Line Cell Nucleus Cercopithecus Aethiops Histone Deacetylases Mice Genetics Research Support, Non-U.S. Gov't Multidisciplinary
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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