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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hermans, Ian F. Ronchese, Franca Yang, Jianping Huck, Stephanie P. Mchugh, Rebecca S. |
| Description | Author Affiliation: Yang J ( Malaghan Institute of Medical Research, Wellington, New Zealand.); |
| Abstract | The lifespan and survival of dendritic cells (DC) in vivo are potentially critical to the expansion of T cell immune responses. We have previously reported that DC loaded with specific antigen are rapidly eliminated by cytotoxic T lymphocytes (CTL) in vivo, but the site, mechanism, and consequences of DC elimination were not defined. In this article we show that DC elimination in vivo occurs in a perforin-dependent manner and does not require IFN-gamma or the presence of CD4(+)CD25(+) regulatory T cells. Most importantly, failure to eliminate DC had profound consequences on the CTL immune response. Perforin-deficient mice showed a progressive increase in the numbers of antigen-specific CD8(+) T cells after repeated immunizations with DC. In contrast, in control mice the number of antigen-specific CD8(+) T cells did not notably increase with repeated immunizations. Lastly, we also show that CTL-mediated elimination of DC occurs in peripheral tissues but not in the lymph node. Our data suggest that CTL act as 'gatekeepers' that control access of antigen-loaded DC into the lymph node, thereby preventing continued expansion of antigen-specific T cells. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 1 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Dendritic Cells Cytology Immunology Membrane Glycoproteins Metabolism T-Lymphocytes, Cytotoxic Adoptive Transfer Animals Cell Death Cell Proliferation Flow Cytometry Immunization Lymph Nodes Genetics Mice Mice, Inbred C57BL Mice, Knockout Perforin Pore Forming Cytotoxic Proteins Comparative Study Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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