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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kitaura, Jiro Salek-ardakani, Shahram Tanaka, Hiroyuki Nagao, Koichi Nagai, Hiroichi Kawakami, Yu Kawakami, Yuko Xiao, Wenbin Inagaki, Naoki Kawakami, Toshiaki Croft, Michael |
| Description | Author Affiliation: Kawakami Y ( Divisions of Cell Biology and Molecular Immunology, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.); |
| Abstract | Btk plays crucial roles in the differentiation and activation of B and myeloid cells. Despite drastic reductions of other Ig isotypes, paradoxically high IgE responses have been known in btk mutant mice. Here we show that btk(-/-) dendritic cells exhibit a more mature phenotype and a stronger in vitro and in vivo T cell-stimulatory ability than wild-type cells. Increased IgE responses were induced by adoptive transfer of btk(-/-) dendritic cells into mice. Consistent with the stronger T cell-stimulatory ability of btk(-/-) dendritic cells, btk(-/-) mice exhibited enhanced inflammation in Th2-driven asthma and Th1-driven contact sensitivity experiments. These negative regulatory functions of Btk in dendritic cells appear to be mediated mainly through autocrine secretion of IL-10 and subsequent activation of Stat3. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 1 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Cell Differentiation Immunology Dendritic Cells Cytology Interleukin-10 Metabolism Protein-Tyrosine Kinases STAT3 Transcription Factor T-Lymphocytes, Helper-Inducer Adoptive Transfer Animals Asthma Dermatitis, Contact Immunization Immunoblotting Immunoglobulin E Mice Mice, Knockout Genetics Comparative Study Research Support, N.I.H., Extramural Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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