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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Goodman, Andrew L. Vasseur, Perrine Lazdunski, Andrée Bleves, Sophie Filloux, Alain Lory, Stephen Ventre, Isabelle Molin, Søren Vallet-gely, Isabelle Soscia, Chantal |
| Description | Author Affiliation: Ventre I ( Laboratoire d'Ingénierie des Systèmes Macromoléculaires, Centre National de la Recherche Scientifique, Institut de Biologie Structurale et Microbiologie, Unité Propre de Recherche 9027, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France.); |
| Abstract | The opportunistic pathogen Pseudomonas aeruginosa is responsible for a wide range of acute and chronic infections. The transition to chronic infections is accompanied by physiological changes in the bacteria favoring formation of biofilm communities. Here we report the identification of LadS, a hybrid sensor kinase that controls the reciprocal expression of genes for type III secretion and biofilm-promoting polysaccharides. Domain organization of LadS and the range of LadS-controlled genes suggest that it counteracts the activities of another sensor kinase, RetS. These two pathways converge by controlling the transcription of a small regulatory RNA, RsmZ. This work identifies a previously undescribed signal transduction network in which the activities of signal-receiving sensor kinases LadS, RetS, and GacS regulate expression of virulence genes associated with acute or chronic infection by transcriptional and posttranscriptional mechanisms. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 1 |
| Volume Number | 103 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2006-01-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Bacterial Proteins Metabolism Biofilms Growth & Development Gene Expression Regulation, Bacterial Physiology Protein Kinases Pseudomonas Aeruginosa RNA Signal Transduction Virulence Factors Animals CHO Cells Cricetinae Cricetulus Cytotoxicity Tests, Immunologic Microarray Analysis Beta-Galactosidase Comparative Study Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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