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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Restifo, Nicholas P. Grewal, Navrose Klebanoff, Christopher A. Waldmann, Thomas A. Finkelstein, Steven E. Rosenberg, Steven A. Palmer, Douglas C. Theoret, Marc R. Tagaya, Yutaka Spiess, Paul J. Surman, Deborah R. Gattinoni, Luca Lichtman, Michael K. Antony, Paul A. |
| Description | Author Affiliation: Klebanoff CA ( Howard Hughes Medical Institute-National Institutes of Health Research Scholars Program, Bethesda, MD 20814, USA.); |
| Abstract | IL-15 and IL-2 possess similar properties, including the ability to induce T cell proliferation. However, whereas IL-2 can promote apoptosis and limit CD8(+) memory T cell survival and proliferation, IL-15 helps maintain a memory CD8(+) T cell population and can inhibit apoptosis. We sought to determine whether IL-15 could enhance the in vivo function of tumor/self-reactive CD8(+) T cells by using a T cell receptor transgenic mouse (pmel-1) whose CD8(+) T cells recognize an epitope derived from the self/melanoma antigen gp100. By removing endogenous IL-15 by using tumor-bearing IL-15 knockout hosts or supplementing IL-15 by means of exogenous administration, as a component of culture media or as a transgene expressed by adoptively transferred T cells, we demonstrate that IL-15 can improve the in vivo antitumor activity of adoptively transferred CD8(+) T cells. These results provide several avenues for improving adoptive immunotherapy of cancer in patients. |
| ISSN | 00278424 |
| e-ISSN | 10916490 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Issue Number | 7 |
| Volume Number | 101 |
| Language | English |
| Publisher | National Academy of Sciences |
| Publisher Date | 2004-02-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | CD8-Positive T-Lymphocytes Immunology Interleukin-15 Melanoma, Experimental Adoptive Transfer Animals Cytology Metabolism Transplantation Cells, Cultured Immunotherapy Genetics Pharmacology Interleukin-2 Membrane Glycoproteins Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Neoplasm Proteins Receptors, Antigen, T-Cell Gp100 Melanoma Antigen Multidisciplinary |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
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