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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pirinççioglu, Mihdiye Kizil, Göksel Kizil, Murat Kanay, Zeki Ketani, Aydin |
| Description | Country affiliation: Turkey Author Affiliation: Pirinççioglu M ( Chemistry Department, University of Dicle, Diyarbakir, Turkey.); Kizil G ( Chemistry Department, University of Dicle, Diyarbakir, Turkey.); Kizil M ( Chemistry Department, University of Dicle, Diyarbakir, Turkey muratk@dicle.edu.tr.); Kanay Z ( Physiology Department, Faculty of Veterinary Science, University of Dicle, Diyarbakir, Turkey.); Ketani A ( Histology and Embryology Department, Faculty of Veterinary Science, University of Dicle, Diyarbakir, Turkey.) |
| Abstract | Most pomegranate (Punica granatum Linn., Punicaceae) fruit parts are known to possess enormous antioxidant activity. The present study was carried out to determine the phenolic and flavonoid contents of Derik pomegranate juice and determine its effect against carbon tetrachloride (CCl4)-induced toxicity in rats. Animals were divided into four groups (n = 6): group I: control, group II: CCl4 (1 ml/kg), group III: CCl4 + pomegranate juice and group IV: CCl4 + ursodeoxycholic acid (UDCA). Treatment duration was 4 weeks, and the dose of CCl4 was administered once a week to groups II, III and IV during the experimental period. CCl4-treated rats caused a significant increase in serum enzyme levels, such as aspartate aminotransferase, alanine aminotransferase and total bilirubin, and decrease in albumin, when compared with control. Administration of CCl4 along with pomegranate juice or UDCA significantly reduces these changes. Analysis of lipid peroxide (LPO) levels by thiobarbutiric acid reaction showed a significant increase in liver, kidney and brain tissues of CCl4-treated rats. However, both pomegranate juice and UDCA prevented the increase in LPO level. Histopathological reports also revealed that there is a regenerative activity in the liver and kidney cells. Derik pomegranate juice showed to be hepatoprotective against CCl4-induced hepatic injury. In conclusion, present study reveals a biological evidence that supports the use of pomegranate juice in the treatment of chemical-induced hepatotoxicity. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 10 |
| Volume Number | 30 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2014-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Carbon Tetrachloride Toxicity Oxidative Stress Drug Effects Plant Extracts Pharmacology Protective Agents Punicaceae Chemistry Animals Brain Pathology Kidney Lipid Peroxidation Liver Male Rats Rats, Wistar Ursodeoxycholic Acid Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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