NDLI: Selenium pretreatment attenuates formaldehyde-induced genotoxicity in A549 cell lines.

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Selenium pretreatment attenuates formaldehyde-induced genotoxicity in A549 cell lines.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shi, Yu-Qin Chen, Xin Dai, Juan Jiang, Zhong-Fa Li, Ning Zhang, Ben-Yan Zhang, Zhi-Bing
Description	Author Affiliation: Shi YQ ( School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, People's Republic of China.); Chen X ( School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, People's Republic of China.); Dai J ( Wuhan Center for Disease Prevention and Control, Wuhan, Hubei, People's Republic of China.); Jiang ZF ( Hubei Center for Disease Prevention and Control, Wuhan, Hubei, People's Republic of China.); Li N ( Hubei Center for Disease Prevention and Control, Wuhan, Hubei, People's Republic of China.); Zhang BY ( School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, People's Republic of China zbyan1000@163.com.); Zhang ZB ( School of Public Health, Medical College, Wuhan University of Science and Technology, Wuhan, Hubei, People's Republic of China.)
Abstract	Formaldehyde is a major industrial chemical and has been extensively used in the manufacture of synthetic resins and chemicals. Numerous studies indicate that formaldehyde can induce various genotoxic effects in vitro and in vivo. A recent study indicated that formaldehyde impaired antioxidant cellular defences and enhanced lipid peroxidation. Selenium is an important antioxidant. We hypothesized that reactive oxygen species (ROS) and lipid peroxidation are involved in formaldehyde-induced genotoxicity in human lung cancer cell line, A549 cell line. To test the hypothesis, we investigated the effects of selenium on formaldehyde-induced genotoxicity in A549 cell lines. The results indicated that exposure to formaldehyde showed the induction of DNA-protein cross-links (DPCs). Formaldehyde significantly increased the malondialdehyde levels and decreased the activities of superoxide dismutase and glutathione peroxidase. In addition, the activations of necrosis factor-κB (NF-κB) and activator protein 1 (AP-1) were induced by the formaldehyde treatment. The pretreatment with selenium counteracted the formaldehyde-induced oxidative stress, ameliorated DPCs and attenuated the activation of NF-κB and AP-1 in A549 cell lines. All the results suggested that the pretreatment with selenium attenuated the formaldehyde-induced genotoxicity through its ROS scavenging and anti-DPCs effects in A549 cell lines.
File Format	HTM / HTML
ISSN	07482337
Issue Number	10
Volume Number	30
e-ISSN	14770393
Journal	Toxicology and Industrial Health
Language	English
Publisher	Sage Publications
Publisher Date	2014-11-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Occupational Medicine Discipline Toxicology Dna Damage Formaldehyde Toxicity Oxidative Stress Drug Effects Selenium Pharmacology Cell Line, Tumor Humans Malondialdehyde Metabolism Mutagenicity Tests Nf-kappa B Chemistry Superoxide Dismutase Transcription Factor Ap-1 Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology

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Selenium pretreatment attenuates formaldehyde-induced genotoxicity in A549 cell lines.