| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Türk, Gaffari Çeribasi, Songül Sönmez, Mustafa Çiftçi, Mehmet Yüce, Abdurrauf Güvenç, Mehmet Kaya, Seyma Özer Çay, Mehmet Aksakal, Mesut |
| Description |
Country affiliation: Turkey Author Affiliation: Türk G ( Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey gaffariturk@hotmail.com.); Çeribasi S ( Department of Pathology, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.); Sönmez M ( Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.); Çiftçi M ( Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.); Yüce A ( Department of Physiology, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.); Güvenç M ( Department of Physiology, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.); Kaya SÖ ( Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.); Çay M ( Department of Physiology, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.); Aksakal M ( Department of Physiology, Faculty of Veterinary Medicine, Firat University, Elazig, Turkey.) |
| Abstract |
The aim of this study was to investigate whether pomegranate juice (PJ) consumption has an ameliorating effect on carbon tetrachloride (CCl4)-induced sperm damages and testicular apoptosis associated with the oxidative stress in male rats. The study comprised of four groups (groups 1-4). Group 1 received olive oil + distilled water daily; group 2 was treated with 5 ml/kg PJ + olive oil daily; group 3 was treated with 0.25 ml/kg CCl4 dissolved in olive oil, weekly + distilled water daily; and group 4 received weekly CCl4 + daily PJ. All administrations were performed by gavage and maintained for 10 weeks. CCl4 administration caused significant decreases in body and reproductive organ weights, sperm motility, concentration and testicular catalase activity, significant increases in malondialdehyde (MDA) level, and abnormal sperm rate and apoptotic index along with some histopathological damages when compared with the control group. However, significant ameliorations were observed in absolute weights of testis and epididymis, all sperm quality parameters, MDA level, apoptotic index, and testicular histopathological structure following the administration of CCl4 together with PJ when compared with group given CCl4 only. In conclusion, PJ consumption ameliorates the CCl4-induced damages in male reproductive organs and cells by decreasing the lipid peroxidation. |
| File Format |
HTM / HTML |
| ISSN |
07482337 |
| Issue Number |
1 |
| Volume Number |
32 |
| e-ISSN |
14770393 |
| Journal |
Toxicology and Industrial Health |
| Language |
English |
| Publisher |
Sage Publications |
| Publisher Date |
2016-01-01 |
| Publisher Place |
Great Britain (UK) |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Occupational Medicine Discipline Toxicology Apoptosis Drug Effects Carbon Tetrachloride Toxicity Fruit And Vegetable Juices Lipid Peroxidation Punicaceae Chemistry Spermatozoa Testis Animals Antioxidants Pharmacology Epididymis Male Malondialdehyde Metabolism Organ Size Oxidative Stress Rats Rats, Wistar Sperm Motility Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
