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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Palanisamy, N. Manian, S. |
| Description | Country affiliation: India Author Affiliation: Palanisamy N ( Department of Biochemistry, Centre for Biological Sciences, KSR College of Arts and Science, Tiruchegode, Tamil Nadu, India. nalpybiochem@gmail.com) |
| Abstract | To investigate the hepatoprotective activity of Asparagus racemosus against isoniazid-induced hepatotoxicity in male albino rats. Rats (n = 6 per group)were divided into four groups: saline-treated control, saline-treated control with A. racemosus extract (50 mg/kg), isoniazid treatment alone (100 mg/kg, intraperitoneal [i.p.]), and isoniazid-A. racemosus extract (50 mg/kg)administered orally as cotreatment. Animals were treated for 21 days and euthanized 1 h after the last drug administration. Evaluated body weight, serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, g-glutamyl transferase, total protein, albumin, hepatic malondialdehyde content, superoxide dismutase, catalase, cytochrome P450 2E1 (CYP2E1)activity and glutathione (GSH). A. racemosus extract prevented isoniazid-induced hepatotoxicity, indicated by both diagnostic indicators of liver damage, liver functional profile, significantly (p < 0.05)inhibited CYP2E1 activity, markedly attenuated oxidative stress by improved enzymatic, non-enzymatic antioxidants levels and mitigate malondialdehyde, lipid hydroperoxide significantly (p < 0.05). These results suggest that A. racemosus extract exerts its hepatoprotective activity by inhibiting the production of free radicals and acts as a scavenger, reducing the free radical generation via inhibition of hepatic CYP2E1 activity, increasing the removal of free radicals through the induction of antioxidant enzymes and improving non-enzymatic thiol antioxidant GSH. |
| File Format | HTM / HTML |
| ISSN | 07482337 |
| Issue Number | 3 |
| Volume Number | 28 |
| e-ISSN | 14770393 |
| Journal | Toxicology and Industrial Health |
| Language | English |
| Publisher | Sage Publications |
| Publisher Date | 2012-04-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Occupational Medicine Discipline Toxicology Antioxidants Pharmacology Asparagus Plant Chemistry Drug-induced Liver Injury Drug Therapy Isoniazid Toxicity Oxidative Stress Drug Effects Plant Extracts Animals Metabolism Enzymes Blood Lipid Peroxidation Liver Enzymology Liver Function Tests Male Plant Roots Rats Rats, Wistar Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology |
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