NDLI: Screening of the toxic effects of a high melamine dose on the biochemical hematological and histopathological investigations in male rats.

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Screening of the toxic effects of a high melamine dose on the biochemical hematological and histopathological investigations in male rats.

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Screening of the toxic effects of a high melamine dose on the biochemical hematological and histopathological investigations in male rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	El Rabey, Haddad A. Al-Sieni, Abdulbasit I. Majami, Abdullah A.
Description	Country affiliation: Egypt Author Affiliation: El Rabey HA ( Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia Bioinformatics Department, Genetic Engineering and Biotechnology Research Institute, Minufiya University, Sadat City, Egypt elrabey@hotmail.com.); Al-Sieni AI ( Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.); Majami AA ( SFDA, Jeddah, Saudi Arabia.)
Abstract	Screening of the toxic effect of a high oral melamine dose (30,000 ppm supplemented in the diet) was performed for 28 days on male rats. The morphology, anatomy, complete blood count (CBC), serum electrolytes, kidney function, serum proteins, serum bilirubin, serum liver enzymes, catalase, glutathion-S-transferase, lipid peroxide, serum melamine concentration, total body weight, food intake, food efficiency ratio (FER), body weight gain percentage (BWG%), body weight gain, water consumption, and histopathological examinations of kidney, urinary bladder, testis, liver, heart, and spleen were investigated. The melamine-supplemented rats turned yellow and showed different degrees of hypertrophy and congestion, particularly the kidney and the ureter as a result of melamine toxicity. The CBC showed minimal changes in the melamine-supplemented groups. Na and Cl were decreased, whereas K, P, and Ca were increased. Serum creatinine, uric acid, and urea were elevated. Liver function enzymes were nonsignificantly affected. Catalase and glutathion-S-transferase were decreased, whereas lipid peroxide was increased in the kidney tissue homogenate. It was also noted that serum protein was decreased and serum bilirubin was increased. Histopathologically, most examined organs were severely injured specially the kidneys, liver, and testes.
File Format	HTM / HTML
ISSN	07482337
Issue Number	10
Volume Number	30
e-ISSN	14770393
Journal	Toxicology and Industrial Health
Language	English
Publisher	Sage Publications
Publisher Date	2014-11-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Occupational Medicine Discipline Toxicology Body Weight Drug Effects Kidney Liver Triazines Toxicity Animals Blood Cell Count Eating Enzymes Blood Hair Pathology Enzymology Male Rats Rats, Wistar Administration & Dosage Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health Toxicology

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