NDLI: MUC1 expression in pulmonary metastatic tumors: a comparison of primary lung cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kaira, Kyoichi Okumura, Takehiro Nakagawa, Kazuo Ohde, Yasuhisa Takahashi, Toshiaki Murakami, Haruyasu Naito, Tateaki Endo, Masahiro Kondo, Haruhiko Nakajima, Takashi Yamamoto, Nobuyuki
Description	Country affiliation: Japan Author Affiliation: Kaira K ( Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka, 411-8777, Japan. kkaira1970@yahoo.co.jp)
Abstract	MUC1 expression has been described as a predictor for tumor progression and worsening of prognosis in various human neoplasms. However, little is known about the role of MUC1 expression in pulmonary metastatic tumors. The aim of this study is to examine the clinicopathological significance of MUC1 expression in pulmonary metastatic tumors (PMT). One hundred forty-seven patients with PMT who underwent (18)F-FDG PET before metastasectomy were included in this study. Tumor sections were stained by immunohistochemistry for MUC1, glucose transporter 1 (Glut1), hypoxia-inducible-1 (HIF-1 ) and vascular endothelial growth factor (VEGF). (18)F-FDG uptake and the expression of these biomarkers were correlated in primary lung cancer. MUC1 expression pattern was classified into high-grade polarized expression (HP), low-grade polarized expression (LP), or depolarized expression (DP) group. Of 147 patients, HP, LP and DP group were 9 (6%), 114 (78%) and 24 (16%), respectively. The expression of Glut1, HIF-1 and VEGF, and (18)F-FDG uptake were significantly higher in DP group than HP or LP groups. MUC1 expression with HP and DP pattern was significantly higher in primary lung cancer than in PMT, whereas, MUC1 expression with LP pattern yielded a significantly high positive rate in PMT. LP group was recognized in the majority of patients with pulmonary metastatic adenocarcinoma, especially colon cancer, whereas, HP group was significantly low in pulmonary metastatic adenocarcinoma as compared with primary adenocarcinoma. Polarized MUC1 has a different expression pattern between primary and metastatic tumors with adenocarcinoma, and depolarized MUC1 is closely associated with glucose metabolism and hypoxia.
File Format	HTM / HTML
ISSN	12194956
Issue Number	2
Volume Number	18
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2012-04-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Adenocarcinoma Secondary Tumor Markers, Biological Metabolism Carcinoma, Non-small-cell Lung Lung Neoplasms Pathology Mucin-1 Adolescent Adult Aged Aged, 80 And Over Female Fluorodeoxyglucose F18 Follow-up Studies Humans Immunoenzyme Techniques Male Metastasectomy Middle Aged Neoplasm Grading Neoplasm Staging Positron-emission Tomography Prognosis Radiopharmaceuticals Young Adult Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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