NDLI: Effect of shRNA mediated down-regulation of Annexin A2 on biological behavior of human lung adencarcinoma cells A549.

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Effect of shRNA mediated down-regulation of Annexin A2 on biological behavior of human lung adencarcinoma cells A549.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Wang, Yue-xiang Lv, Hui Li, Ze-xia Li, Cui Wu, Xiao-ying
Description	Author Affiliation: Wang YX ( Department of Medical Ultrastructure, Xiangya School of Medicine, Central South University, Changsha, Hunan, 410078, People's Republic of China.)
Abstract	In the previous study, we found that Annexin A2 was significantly up-regulated in lung cancer and could induce related-antigen in lung cancer patients' serum. To further study the function of Annexin A2, the short hairpin RNA plasmid targeting Annexin A2 was constructed in vitro and transfected into human lung adencarcinoma A549 cells. Knocking down Annexin A2 expression by shRNA, the mRNA level of Annexin A2 was investigated by semi-quantitative RT-PCR. The expression of Annexin A2 protein was examined by Western Blotting and Immuocytochemistry. MTT assay and Transwell chamber model were used to evaluate proliferation and invasion of A549 cells in vitro. The concentration of matrix metalloproteinase-2 (MMP-2) and cathepsin B (CB) in the supernatant was evaluated by ELISA. At 48 h after transfection, the expression of Annexin A2 mRNA and protein was down-regulated significantly, respectively (p < 0.05).The proliferation and invasion capability of A549 cells also decreased significantly (p < 0.05). The concentration of MMP-2 and CB was down-regulated obviously, respectively (p < 0.05). This study implies that Annexin A2 might play an important role in the progression and invasion of human lung cancer cells, and could promote progression of lung cancer by regulating the expression of MMP-2 and CB.
File Format	HTM / HTML
ISSN	12194956
Issue Number	2
Volume Number	18
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2012-04-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Annexin A2 Antagonists & Inhibitors Metabolism Cathepsin B Lung Neoplasms Pathology Matrix Metalloproteinase 2 Rna, Small Interfering Genetics Adenocarcinoma Blotting, Western Cell Adhesion Cell Line, Tumor Cell Movement Cell Proliferation Down-regulation Enzyme-linked Immunosorbent Assay Humans Immunoenzyme Techniques Neoplasm Invasiveness Rna, Messenger Real-time Polymerase Chain Reaction Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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