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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dundr, Pavel Fischerová, Daniela Povýsil, Ctibor Tvrdík, Daniel Cibula, David |
| Description | Country affiliation: Czech Republic Author Affiliation: Dundr P ( Department of Pathology, First Faculty of Medicine and General University Hospital, Charles University in Prague, Studnickova 2, Prague 2, 12800, Czech Republic. pdundr@seznam.cz) |
| Abstract | We report a case of a 52-year-old female with synovial sarcoma of the uterine corpus. Grossly, the partly polypoid tumor involved the endometrium with invasion into the inner half of the myometrium. Histologically, the tumor showed biphasic structure with the predominance of poorly differentiated small to medium sized round to oval cells. These cells showed high nuclear to cytoplasmic ratio and were arranged in diffuse sheets. Other component consisted of larger epitheloid cells with ample eosinophilic cytoplasm arranged in irregular nests. These cells were only present in a small amount. Immunohistochemically, the tumor cells in both components showed the expression of EMA, S-100 protein, CD99, and NSE. RT-PCR analysis showed the presence of SYT-SSX1 fusion transcript. At present, the patient shows no signs of tumor relapse 56 months after the diagnosis. To the best of our knowledge, this is the first report of synovial sarcoma arising in uterus. |
| File Format | HTM / HTML |
| ISSN | 12194956 |
| Issue Number | 2 |
| Volume Number | 18 |
| e-ISSN | 15322807 |
| Journal | Pathology & Oncology Research |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2012-04-01 |
| Publisher Place | Netherlands |
| Access Restriction | Subscribed |
| Subject Keyword | Discipline Oncology Neoplasms, Second Primary Pathology Sarcoma, Synovial Uterine Cervical Neoplasms Female Humans Immunoenzyme Techniques Middle Aged Genetics Oncogene Proteins, Fusion Rna, Messenger Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Case Reports Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Case study Article |
| Subject | Cancer Research Pathology and Forensic Medicine Oncology |
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