NDLI: Indeterminate cell histiocytosis in a pediatric patient: successful treatment with thalidomide.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tóth, Béla Katona, Mária Hársing, Judit Szepesi, Agota Kárpáti, Sarolta
Description	Country affiliation: Hungary Author Affiliation: Tóth B ( Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Mária utca 41, 1085, Budapest, Hungary. tothbela@bor.sote.hu)
Abstract	The 15-year-old male patient presented several 2-6 mm large livid reddish-yellowish, shiny, compact papules on the head, trunk and extremities, which had developed within the last 4 months. Histology showed normal epidermis with dense dermal infiltrate of histiocytes accompanied by few eosinophils, Touton or foamy giant cells. The histiocytes were S100 positive, CD1a negative and did not contain Birbeck granules ultrastructurally. Chest X ray, EEG, skull MRI did not show pathology. Opthalmology, neurology, oto-rhino-laryngology did not reveal alterations. Based upon the clinical symptoms and the histopathology, the diagnosis of indeterminate cell histiocytosis was confirmed. Cryotherapy and cauterization did not stop the progression of the disease, however, under thalidomide treatment no new symptoms developed and the lesions healed with pigmentation.
File Format	HTM / HTML
ISSN	12194956
Issue Number	2
Volume Number	18
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2012-04-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Histiocytosis Drug Therapy Immunosuppressive Agents Therapeutic Use Skin Diseases Thalidomide Adolescent Pathology Humans Male Treatment Outcome Case Reports Journal Article
Content Type	Text
Resource Type	Case study Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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