NDLI: Aldehyde Dehydragenase 1 and Nodal as Significant Prognostic Markers in Colorectal Cancer.

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Aldehyde Dehydragenase 1 and Nodal as Significant Prognostic Markers in Colorectal Cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Hui Jiang, Yang Pei, Fenghua Li, Lu Yan, Bingzhu Geng, Xinyu Liu, Bingrong
Description	Author Affiliation: Li H ( Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Xuefu Road 246, Nangang District, Harbin, 150001, Heilongjiang, People's Republic of China.); Jiang Y ( Department of Pathology, Harbin Medical University, Xuefu Road 157, Harbin, 150081, People's Republic of China.); Pei F ( Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Xuefu Road 246, Nangang District, Harbin, 150001, Heilongjiang, People's Republic of China.); Li L ( Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Xuefu Road 246, Nangang District, Harbin, 150001, Heilongjiang, People's Republic of China.); Yan B ( Department of Infectious Disease, The Second Affiliated Hospital of Harbin Medical University, Xuefu Road 246, Harbin, Heilongjiang, 150001, People's Republic of China.); Geng X ( Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Xuefu Road 246, Nangang District, Harbin, 150001, Heilongjiang, People's Republic of China.); Liu B ( Department of Gastroenterology, The Second Affiliated Hospital of Harbin Medical University, Xuefu Road 246, Nangang District, Harbin, 150001, Heilongjiang, People's Republic of China. bingrongliu1963@126.com.)
Abstract	This study aimed to analyze prognostic significance of aldehyde dehydragenase 1 (ALDH1) and Nodal expression in patients with colorectal cancer. ALDH1 and Nodal expressions were observed based on the immunohistochemistry staining from 108 colorectal cancer patients. Scores were given to the staining intensity and percentage of positive cells, and sum of two scores for each case was used to define the groups of ALDH1 and Nodal. We also investigated the protein and mRNA levels of ALDH1 and Nodal by Western blot and qRT-PCR assays. The results were analyzed with the clinicopathologic parameters of these patients. The results indicated that expressions of ALDH1 and Nodal were significantly correlated with the differentiation degree, metastasis, number of tumor positive lymph nodes and AJCC stage. ALDH1 was inclined to express more in the worse differentiated degrees, lymph node metastasis, and worse AJCC stage of colorectal cancer patients. And the expression of Nodal was inversely compared with ALDH1.While the expression of ALDH1 was inversely correlated with the Nodal (r = -0.709, P < 0.01).
File Format	HTM / HTML
ISSN	12194956
Issue Number	1
Volume Number	22
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2016-01-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Tumor Markers, Biological Metabolism Colorectal Neoplasms Isoenzymes Nodal Protein Retinal Dehydrogenase Aged Genetics Blotting, Western Pathology Female Follow-up Studies Humans Immunoenzyme Techniques Lymphatic Metastasis Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Prognosis Rna, Messenger Real-time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Journal Article
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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