NDLI: Morphologic Features and Clinical Impact of Arteritis Concurrent with Transplant Glomerulopathy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Dobi, Deján Bodó, Zsolt Kemény, Éva Boda, Krisztina Szenohradszky, Pál Szederkényi, Edit Laszik, Zoltan G. Iványi, Béla
Description	Country affiliation: Hungary Author Affiliation: Dobi D ( Department of Pathology, University of Szeged, Allomas u. 2., H-6720, Szeged, Hungary. dobi.dejan@gmail.com.); Bodó Z ( Department of Pathology, University of Szeged, Allomas u. 2., H-6720, Szeged, Hungary.); Kemény É ( Department of Pathology, University of Szeged, Allomas u. 2., H-6720, Szeged, Hungary.); Boda K ( Department of Medical Physics and Informatics, University of Szeged, Koranyi fasor 9., H-6720, Szeged, Hungary.); Szenohradszky P ( Department of Surgery, University of Szeged, Szokefalvi-Nagy u. 6., H-6720, Szeged, Hungary.); Szederkényi E ( Department of Surgery, University of Szeged, Szokefalvi-Nagy u. 6., H-6720, Szeged, Hungary.); Laszik ZG ( Department of Pathology, University of California, San Francisco, 513 Parnassus Avenue, Room S566, San Francisco, CA, 94143-0102, USA.); Iványi B ( Department of Pathology, University of Szeged, Allomas u. 2., H-6720, Szeged, Hungary.)
Abstract	Little is known about the morphology and clinical relevance of arteritis in renal allograft biopsies with transplant glomerulopathy. We retrospectively reviewed the morphologic findings and clinical course of 59 patients with cg, 16 of which featured concurrent arteritis (fibrosing intimal arteritis with luminal narrowing in 15, and acute intimal arteritis in 1 case). Fifteen out of the 16 cases with arteritis fulfilled the morphological diagnostic criteria for chronic active antibody-mediated rejection, and 11 cases with arteritis showed morphological evidence of concurrent, ongoing T-cell-mediated alloimmune response (acute T-cell-mediated rejection in 5, borderline changes in 6 cases). Further, the Banff grades of interstitial inflammation in scarred and nonscarred cortex, total cortical inflammation, and arterial luminal narrowing were significantly higher in biopsies with arteritis. By immunohistochemistry, T-lymphocyte predominance over macrophages was found in the intimal infiltrates in 14 out of 16 cases, and cytotoxic T-lymphocytes were identified among intimal mononuclears in 10 cases. Patients with arteritis demonstrated a significantly shorter renal survival (7.5 vs. 29 months). In conclusion, T-cell-mediated mechanisms could play a role in the development of arteritis concurrent with cg. However, this finding does not exclude the possibility that antibody-mediated rejection can also contribute to the evolution of the lesion. Importantly, the lesion carries negative prognostic value likely via severe arterial luminal narrowing.
File Format	HTM / HTML
ISSN	12194956
Issue Number	1
Volume Number	22
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2016-01-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Arteritis Pathology Glomerulonephritis Graft Rejection Graft Survival Inflammation Kidney Diseases Surgery Kidney Transplantation Adverse Effects Adult Etiology Female Follow-up Studies Humans Image Interpretation, Computer-assisted Immunophenotyping Macrophages Male Middle Aged Prognosis Retrospective Studies T-lymphocytes Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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