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Genetic Alterations in Hungarian Patients with Papillary Thyroid Cancer.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Tobiás, Bálint Halászlaki, Csaba Balla, Bernadett Kósa, János P. Árvai, Kristóf Horváth, Péter Takács, István Nagy, Zsolt Horváth, Evelin Horányi, János Járay, Balázs Székely, Eszter Székely, Tamás Gyori, Gabriella Putz, Zsuzsanna Dank, Magdolna Valkusz, Zsuzsanna Vasas, Béla Iványi, Béla Lakatos, Péter
Spatial Coverage	Hungary
Description	Country affiliation: Hungary Author Affiliation: Tobiás B ( 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary. tobias.balint@med.semmelweis-univ.hu.); Halászlaki C ( 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary.); Balla B ( 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary.); Kósa JP ( 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary.); Árvai K ( PentaCore Laboratory, Budapest, Hungary.); Horváth P ( PentaCore Laboratory, Budapest, Hungary.); Takács I ( 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary.); Nagy Z ( 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary.); Horváth E ( 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary.); Horányi J ( 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary.); Járay B ( 1st Department of Surgery, Semmelweis University, Budapest, Hungary.); Székely E ( 2nd Department of Pathology, Semmelweis University, Budapest, Hungary.); Székely T ( 2nd Department of Pathology, Semmelweis University, Budapest, Hungary.); Gyori G ( 2nd Department of Pathology, Semmelweis University, Budapest, Hungary.); Putz Z ( Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary.); Dank M ( 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary.); Valkusz Z ( 1st Department of Internal Medicine, Semmelweis University, Korányi S. Str. 2a, Budapest, 1083, Hungary.); Vasas B ( Department of Medicine, University of Szeged, Szeged, Hungary.); Iványi B ( Department of Pathology, University of Szeged, Szeged, Hungary.); Lakatos P ( Department of Pathology, University of Szeged, Szeged, Hungary.)
Abstract	The incidence of thyroid cancers is increasing worldwide. Some somatic oncogene mutations (BRAF, NRAS, HRAS, KRAS) as well as gene translocations (RET/PTC, PAX8/PPAR-gamma) have been associated with the development of thyroid cancer. In our study, we analyzed these genetic alterations in 394 thyroid tissue samples (197 papillary carcinomas and 197 healthy). The somatic mutations and translocations were detected by Light Cycler melting method and Real-Time Polymerase Chain Reaction techniques, respectively. In tumorous samples, 86 BRAF (44.2%), 5 NRAS (3.1%), 2 HRAS (1.0%) and 1 KRAS (0.5%) mutations were found, as well as 9 RET/PTC1 (4.6%) and 1 RET/PTC3 (0.5%) translocations. No genetic alteration was seen in the non tumorous control thyroid tissues. No correlation was detected between the genetic variants and the pathological subtypes of papillary cancer as well as the severity of the disease. Our results are only partly concordant with the data found in the literature.
File Format	HTM / HTML
ISSN	12194956
Issue Number	1
Volume Number	22
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2016-01-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Tumor Markers, Biological Genetics Carcinoma, Papillary Mutation Proto-oncogene Proteins B-raf Thyroid Neoplasms Ras Proteins Epidemiology Pathology Case-control Studies Female Follow-up Studies Genotype Humans Hungary Male Middle Aged Neoplasm Staging Prognosis Real-time Polymerase Chain Reaction Comparative Study Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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