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The overexpression of AP-4 as a prognostic indicator for gastric carcinoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Xinghua, Liu Bo, Zhang Yan, Guo Lei, Wu Changyao, Wu Qi, Liang Lin, Ye Kaixiong, Tao Guobin, Wang Jianying, Chen
Description	Country affiliation: China Author Affiliation: Xinghua L ( Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.)
Abstract	As a transcription factor belonging to the basic helix-loop-helix leucine-zipper subgroup, AP-4 can control target gene expression by altering cell signal transduction, and regulate growth, development, and cell apoptosis. Under pathological circumstances, it is involved in tumorigenesis. Herein, immunohistochemistry and real-time PCR were used to detect the transcription factor AP-4 expression in gastric cancer, and these data were examined for correlation with histology, pTNM stage, and prognosis. The AP-4 expression rate was 83.67% in a total of 98 gastric cancer tissues, which was significantly higher than 40.91% in non-neoplastic tissues; AP-4 mRNA relative expression shows a significant difference between gastric cancer and normal tissues, and AP-4 expression has a significantly positive correlation with the depth of tumor invasion (P < 0.0001), degree of tumor differentiation (P = 0.0058), lymph node metastasis (P = 0.0255), and pTNM stage (P = 0.001). Survival analysis showed that AP-4-positive patients' median survival time (12.60 months) was significantly shorter than that (41.40 months) of AP-4-negative patients. AP-4 expression in gastric cancer is associated with clinicopathological parameters of gastric cancer, such as differentiation, lymph node metastasis, depth of invasion (P = 0.0010), and pTNM stage. What's more, AP-4 overexpression indicated a worse prognosis for patients. So AP-4 may be a molecular marker to predict the progression and prognosis of the tumor.
File Format	HTM / HTML
ISSN	13570560
Issue Number	2
Volume Number	29
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2012-06-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Research Support, Non-u.s. Gov't Dna-binding Proteins Prognosis Comparative Study Humans Middle Aged Male Immunoenzyme Techniques Journal Article Young Adult Case-control Studies Adult Genetics Female Stomach Neoplasms Discipline Oncology Stomach Tumor Markers, Biological Neoplasm Invasiveness Rna, Messenger Mortality Real-time Polymerase Chain Reaction Survival Rate Lymphatic Metastasis Metabolism Aged, 80 And Over Reverse Transcriptase Polymerase Chain Reaction Pathology Follow-up Studies Transcription Factors Aged Neoplasm Staging
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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