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Epidemiological, Clinicopathological and Virological Features of Merkel Cell Carcinomas in Medical Center of University of Pécs, Hungary (2007-2012).

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Horváth, Katalin Barbara Pankovics, Péter Kálmán, Endre Kádár, Zsolt Battyáni, Zita Lengyel, Zsuzsanna Reuter, Gábor
Spatial Coverage	Hungary
Description	Country affiliation: Hungary Author Affiliation: Horváth KB ( Regional Laboratory of Virology, ÁNTSZ Regional Institute of State Public Health Service, Szabadság út 7., Pécs, H-7623, Hungary.); Pankovics P ( Department of Pathology, University of Pécs, Pécs, Hungary.); Kálmán E ( Regional Laboratory of Virology, ÁNTSZ Regional Institute of State Public Health Service, Szabadság út 7., Pécs, H-7623, Hungary.); Kádár Z ( Department of Pathology, University of Pécs, Pécs, Hungary.); Battyáni Z ( Department of Dermatology, Venereology and Oncodermatology, University of Pécs, Pécs, Hungary.); Lengyel Z ( Department of Dermatology, Venereology and Oncodermatology, University of Pécs, Pécs, Hungary.); Reuter G ( Department of Dermatology, Venereology and Oncodermatology, University of Pécs, Pécs, Hungary.)
Abstract	Merkel cell carcinoma (MCC) is a rare, highly aggressive skin tumour. In 2008, a Merkel cell polyomavirus (MC) was identified in MCCs as a potential etiological factor of MCC. The aims of this retrospective study were to investigate the epidemiological, clinicopathological and virological features of MCCs. Between 2007 and 2012, 11 patients had been diagnosed with MCC by histological methods in University of Pécs, Hungary. In eight MCC cases MC was tested by PCR (in primary skin lesions, lymph nodes/cutan metastases, MCC neighboring carcinomas). Clinicopathological characteristics (age, histological pattern, lymphovascular invasion, co-morbidities) of MC-positive and MC-negative cases were compared. MC was detected in three (37.5%) out of eight patients' primary tumour or metastasis. The average age was 73.8 (64.3 in MC-positive group). Except the youngest, 55 year-old patient (the primary tumour appeared on his leg), all tumours were found at the head and neck region. Immunosuppression (steroid therapy, chronic lymphoid leukaemia, chronic obstructive pulmonary disease) and/or old age were characteristic for all cases. Histological pattern was different in MC-positive and in MC-negative groups: MCCs with MC showed more homogeneous histological pattern, lack of lymphovascular invasion and were associated with better prognosis (mortality rate: 33% versus 80%). MCC associated with oncogenic virus is a newly recognized clinical entity. However, MC could not be detected in all histologically proven MCCs. The well-defined selection of patients/disease groups and better characterization of differences between MC-positive and negative cases is an important step towards the recognition of the etiology and pathogenesis of all MCCs.
File Format	HTM / HTML
ISSN	12194956
Issue Number	1
Volume Number	22
e-ISSN	15322807
Journal	Pathology & Oncology Research
Language	English
Publisher	Springer
Publisher Date	2016-01-01
Publisher Place	Netherlands
Access Restriction	Subscribed
Subject Keyword	Discipline Oncology Carcinoma, Basal Cell Epidemiology Carcinoma, Merkel Cell Carcinoma, Squamous Cell Dna, Viral Genetics Polyomavirus Infections Skin Neoplasms Tumor Virus Infections Aged Aged, 80 And Over Pathology Virology Female Follow-up Studies Humans Hungary Lymphatic Metastasis Male Merkel Cell Polyomavirus Pathogenicity Middle Aged Neoplasm Staging Polymerase Chain Reaction Prognosis Retrospective Studies Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pathology and Forensic Medicine Oncology

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Epidemiological, Clinicopathological and Virological Features of Merkel Cell Carcinomas in Medical Center of University of Pécs, Hungary (2007–2012)

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Epidemiological, Clinicopathological and Virological Features of Merkel Cell Carcinomas in Medical Center of University of Pécs, Hungary (2007-2012).

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Epidemiological, Clinicopathological and Virological Features of Merkel Cell Carcinomas in Medical Center of University of Pécs, Hungary (2007-2012).