| Author |
Chen, Yun-Chi Fang, Wen-Liang Wang, Ruei-Fang Liu, Chien-An Yang, Muh-Hwa Lo, Shu-Shun Wu, Chew-Wen Li, Anna Fen-Yau Shyr, Yi-Ming Huang, Kuo-Hung |
| Description |
Country affiliation: China Author Affiliation: Chen YC ( Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, 11217, Republic Of China.); Fang WL ( School of Medicine, National Yang-Ming University, Taipei, Taiwan.); Wang RF ( Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, No.201, Sec. 2, Shipai Rd., Beitou District, Taipei, Taiwan, 11217, Republic Of China.); Liu CA ( School of Medicine, National Yang-Ming University, Taipei, Taiwan.); Yang MH ( Department of Emergency Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.); Lo SS ( School of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.); Wu CW ( School of Medicine, National Yang-Ming University, Taipei, Taiwan.); Li AF ( Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan.); Shyr YM ( Institute of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan.); Huang KH ( Division of Hematology-Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.) |
| Abstract |
The investigation of prognostic factor for gastric cancer is still desirable because of dismal prognosis in gastric cancer. Lauren's classification is currently a useful histological classification. There are few large series evaluating the prognostic significance of Lauren's classification in gastric cancer. From January 1987 to December 2013, a total of 3071 patients received gastrectomy for gastric cancer. According Lauren's classification, 1423(46.3%) patients were intestinal type, 1000 patients (32.6%) were diffuse type, and 648 patients (21.1%) were mixed type. The clinicopathological characteristics and prognosis in Lauren's classification were analyzed in these patients. Our results showed that patients with intestinal type gastric cancer (57.7%) had a better 5-year overall survival than diffuse type (45.6%) and mixed type (43.4%, P < 0.001). The clinicopathological characteristics showed that gastric cancer patients with intestinal type were older (P < 0.001), male predominant (P < 0.001), smaller tumor size (P < 0.001), distal stomach predominant (P < 0.001), relative well differentiated (P < 0.001), less advanced Borrmann type (P < 0.001), less scirrhous type stromal reaction(P < 0.001), less infiltrating type of Ming's histology type(P < 0.001), less tumor invasion depth and less lymphovascular invasion (P < 0.001). Multivariate analysis with overall survival as an endpoint showed that age (P = 0.005), Borrmann classification (P < 0.001), pathological T category (P = 0.023), pathological N category (P < 0.001) and Lauren's classification (P = 0.003) were significant correlated in gastric cancer. Lauren's classification is an independent prognostic factor in gastric cancer patient undergoing gastrectomy. Lauren's classification can serve as a prognostic marker for gastric cancer patient receiving gastrectomy. The clinicopathological appearance and prognosis of mixed type gastric cancer is similar to diffuse type gastric cancer. |
