NDLI: Ambulatory blood pressure monitoring and structural changes in carotid arteries in normotensive workers occupationally exposed to lead.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Poreba, Rafal Poreba, Malgorzata Gac, Pawel Andrzejak, Ryszard
Description	Country affiliation: Poland Author Affiliation: Poreba R ( Department of Internal Medicine, Occupational Diseases and Hypertension, Wroclaw Medical University, Pasteur 4, PL 50-367 Wroclaw, Poland. sogood@poczta.onet.pl)
Abstract	Occupational exposure to lead may cause an increase in blood pressure. The aim of the study was to estimate the effect of occupational exposure to lead on selected parameters of ambulatory blood pressure monitoring (ABPM) and structural changes in carotid arteries. The study included 33 normotensive men occupationally exposed to lead and 39 unexposed men employed in administration of the foundry. All of the men underwent 24-hour ambulatory blood pressure monitoring and high-resolution B-mode ultrasonography to determine intima-media thickness (IMT). The group of men occupationally exposed to lead manifested significantly higher mean systolic blood pressure (MSBP), mean diastolic blood pressure (MDBP), mean blood pressure (MBP), pulse pressure (PP), variability of diastolic blood pressure (VDBP), and IMT than the unexposed group. The studied groups did not differ in mean values of variability of systolic blood pressure (VSBP). As compared to the unexposed group, in men exposed to lead, atherosclerotic plaques were significantly more common. In the group of persons exposed to lead the Pearson's correlation coefficient analysis revealed significant linear positive correlations between MSBP and IMT, between lead level and the number of atherosclerotic plaques, and between lead level and PP. Multivariate stepwise regression analysis demonstrated that higher lead level in blood and higher triglyceride concentration in blood represent independent risk factors of an increased pulse pressure in the group of individuals occupationally exposed to lead. Occupational exposure to lead can be associated with increased blood pressure and accelerated progression of atherosclerosis.
File Format	HTM / HTML
ISSN	09603271
Issue Number	9
Volume Number	30
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2011-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Blood Pressure Drug Effects Carotid Artery, Common Pathology Hypertension Chemically Induced Lead Toxicity Occupational Diseases Occupational Exposure Adverse Effects Physiology Blood Pressure Monitoring, Ambulatory Humans Blood Male Metallurgy Middle Aged Multivariate Analysis Analysis Regression Analysis Risk Factors Triglycerides Tunica Media Ultrasonography Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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