NDLI: Comparison of the effects of N-acetyl cysteine and erdosteine in rats with renal injury caused by paracetamol intoxication.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kandis, Hayati Erkan, Melih Engin Yildirim, Umran Günes, Harun Erbas, Mesut Yildirim, Hayriye A. K. Gezer, Suat Kara, Ismail Hamdi
Description	Country affiliation: Turkey Author Affiliation: Kandis H ( Department of Emergency Medicine, Faculty of Medicine, Duzce University, Duzce, Turkey. hayatikandis@yahoo.com)
Abstract	AIM: The aim of the present study was to investigate the therapeutic and preventive effects of N-acetyl cysteine and erdosteine on renal injury associated with paracetamol (acetaminophen) intoxication. MATERIALS AND METHODS: Female albino Wistar rats were divided into six groups: control; paracetamol (1 g/kg, oral); paracetamol (1 g/kg, oral) + erdosteine (150 mg/kg/day, oral); paracetamol (1 g/kg, oral) + N-acetyl cysteine (140 mg/kg bolus, followed by 70 mg/kg, oral); N-acetyl cysteine control (140 mg/kg bolus, followed by 70 mg/kg, oral); and erdosteine control (150 mg/kg/day, oral). Potential renal injury was assessed using biochemical analyses, radionuclide imaging, and histopathological parameters. RESULTS: In the paracetamol group, blood urea nitrogen and creatinine levels were significantly increased compared with controls. Histopathological examination showed tubular vacuolization, tubular necrosis, and remarkable interstitial inflammation. The excretion function was observed to be insufficient on radionuclide imaging. However, in the groups treated with erdosteine or N-acetyl cysteine after paracetamol, biochemical analyses, radionuclide imaging, and histopathological parameters showed significantly less evidence of renal toxicity than that observed in the group receiving paracetamol alone. Less renal toxicity was detected in rats receiving N-acetyl cysteine than in those receiving erdosteine. CONCLUSION: Renal injury may develop after paracetamol overdose. Erdosteine and N-acetyl cysteine are both effective in the prevention of renal injury when given in the early phase of paracetamol nephrotoxicity. N-acetyl cysteine is more protective than erdosteine.
File Format	HTM / HTML
ISSN	09603271
Issue Number	9
Volume Number	30
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2011-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Acetaminophen Toxicity Acetylcysteine Therapeutic Use Acute Kidney Injury Prevention & Control Antioxidants Thioglycolates Thiophenes Administration & Dosage Chemically Induced Metabolism Animals Data Interpretation, Statistical Female Kidney Pathology Kidney Function Tests Radionuclide Imaging Rats Rats, Wistar Comparative Study Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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