NDLI: The effect of high-fat diet-induced obesity on cardiovascular toxicity in Wistar albino rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Bhandari, Uma Kumar, Vinay Khanna, Naresh Panda, Bibhu Prasad
Description	Country affiliation: India Author Affiliation: Bhandari U ( Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi, India. uma_bora@hotmail.com)
Abstract	The consumption of a high-fat diet (HFD) is considered a risk factor for obesity development. Nonetheless, a causal role of dietary fat has never been documented, because of inadequate animal models. In our study, one group of rats was fed with standard rat diet, while other group of rats fed with high-fat diet for 4 weeks. After 4 weeks of feeding, the hemodynamic parameters in the rats fed with HFD were significantly increased as compared with control rats. Rats fed with HFD had elevated levels of serum lipids, insulin, leptin, glucose and apolipoprotein B. Lipid peroxides and caspase-3 levels were increased while serum apolipoprotein A1 and antioxidant enzymes levels in heart tissues were decreased in HFD-induced obesity in rats as compared to normal healthy control rats fed on standard rat pellet diet. This model of diet-induced obesity will be a useful tool for studying the mechanisms by which dietary fat induces the obesity in humans.
File Format	HTM / HTML
ISSN	09603271
Issue Number	9
Volume Number	30
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2011-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Cardiovascular Physiological Phenomena Dietary Fats Administration & Dosage Disease Models, Animal Obesity Physiopathology Animals Apolipoprotein A-i Blood Apolipoproteins B Blood Glucose Analysis Caspase 3 Metabolism Hemodynamics Physiology Insulin Leptin Lipid Peroxidation Lipids Male Myocardium Enzymology Pathology Etiology Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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