NDLI: Inhibition effects of the classical pathway complement of isolated compounds from Quercus glauca.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chung, Ill-Min Kim, Eun-Hye Kim, Jong-Jin Moon, Hyung-In
Description	Country affiliation: South Korea Author Affiliation: Chung IM ( Department of Applied Life science, Kon Kuk University, Seoul, South Korea.)
Abstract	Species of the Quercus species is an evergreen broadleaf tree found not only in Korea but also in China, Taiwan, and Japan. Quercus species is the most commonly occurring plant among the 50 native species of the family Fagaceae in Korea, China, and Taiwan. Quercus species have been used for diarrhea, dysentery, dermatitis, and hemorrhagia in Korean folk medicine. The present study evaluated the anticomplement effect of constituents from Quercus species (Fagaceae) in classical pathway complement system. We have evaluated leaves of five species of the Quercus genus with regard to its anticomplement activity and have identified its active principles following activity-guided isolation. Bioactivity-guided fractionation of the 80% methanol extracts of the stem barks of Quercus glauca Thunberg has led to the isolation of galloyl derivatives, displaying high anticomplement activity. Four galloyl derivatives isolated from the leaves of Q. glauca, namely 6'-O-galloyl salidroside (1), methyl gallate (2), 1,2,3,6-tetragalloylglucose (3), and 1,2,6-trigalloylglucose (4). 1, 2, 3 and 4 showed inhibitory activity against complement system with 50% inhibitory concentrations (IC(50)) values of 224 µM, 362.4 µM, 32.3 µM, and 138.3 µM. Among the compounds tested, 3 showed the most potent anticomplement activity (IC(50), 32.3 µM). This is the first report of the isolation and anticomplement activity from Q. glauca.
File Format	HTM / HTML
ISSN	09603271
Issue Number	9
Volume Number	30
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2011-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Complement Inactivating Agents Pharmacology Complement Pathway, Classical Drug Effects Drugs, Chinese Herbal Quercus Chemistry Animals Chromatography, Thin Layer Isolation & Purification Erythrocytes Inhibitory Concentration 50 Plant Bark Plant Leaves Plant Stems Rabbits Sheep Blood Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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