NDLI: Modulatory effects of Moringa oleifera extracts against hydrogen peroxide-induced cytotoxicity and oxidative damage.

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Modulatory effects of Moringa oleifera extracts against hydrogen peroxide-induced cytotoxicity and oxidative damage.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sreelatha, S. Padma, P. R.
Description	Country affiliation: Singapore Author Affiliation: Sreelatha S ( Faculty of Science, NUS, Singapore. sree_latha04@yahoo.com)
Abstract	Studies have demonstrated that the induction of oxidative stress may be involved in oxidative DNA damage. The present study examined and assessed the hydrogen peroxide $(H_{2}O_{2})-mediated$ DNA damage in human tumor KB cells and also assessed the ability of Moringa oleifera leaf extracts to inhibit the oxidative damage. $H_{2}O_{2}$ imposed a stress on the membrane lipids which was quantified by the extent of thiobarbituric acid reactive substances (TBARS) formed. The leaf extracts caused a very significant inhibition of the extent of LPO formation and enhanced the activity of antioxidative enzymes such as superoxide dismutase (SOD) and catalase (CAT) in KB cells. The comet assay was employed to study the DNA damage and its inhibition by the leaf extracts. $H_{2}O_{2}$ caused a significant increase in the number of cells bearing comets, resulting in significant DNA damage. The leaf extracts significantly reduced the incidence of comets in the oxidant stressed cells. The extent of cytotoxicity of $H_{2}O_{2}$ in the presence and the absence of leaf extracts studied in KB tumor cells by the MTT assay showed that $H_{2}O_{2}$ caused a marked decrease in the viability of KB cells where as the leaf extracts effectively increased the viability of assaulted KB cells. The observed cytoprotective activity is probably due to the antioxidant properties of its constituents, mainly phenolics. Total phenolics showed higher correlation with antioxidant activity. The leaf extracts showed higher antioxidant activity than the reference compound. These results suggest that the inhibition by the leaf extracts on oxidative DNA damage could be attributed to their free radical scavenging activities and the effect evidenced in KB cells can be in part correlated to a modulation of redox-sensitive mechanisms.
File Format	HTM / HTML
ISSN	09603271
Issue Number	9
Volume Number	30
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2011-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Dna Damage Drug Effects Hydrogen Peroxide Toxicity Moringa Oleifera Chemistry Oxidative Stress Plant Extracts Pharmacology Antioxidants Metabolism Cell Culture Techniques Cell Survival Comet Assay Humans Kb Cells Lipid Peroxidation Isolation & Purification Plant Leaves Journal Article
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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