NDLI: Decreased antioxidase activities and oxidative stress in the spleen of chickens fed on high-fluorine diets.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Tao Cui, Hengmin Cui, Yun Bai, Caimin Gong, Tao
Description	Country affiliation: China Author Affiliation: Chen T ( Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an, Sichuan, China.)
Abstract	Three hundred one-day-old avian broilers were divided into four equal groups of 75 animals that were fed for 42 days as follows: a control diet containing 23 mg fluorine (F)/kg and three high F diets containing 400, 800, and 1200 mg F/kg, respectively, for high F groups I, II, and III. The superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were greatly decreased, while the malondialdehyde (MDA) contents were markedly increased in high F groups II and III. At the same time, mitochondrial injury and expanded endocytoplasmic reticulum were obviously observed in high F groups II and III, and the fluoride contents both in spleen and serum were significantly increased in the three high F groups when compared with those of control group. The results showed that excess dietary F in the range of 800-1200 mg/kg caused obvious oxidative stress, which provided a possible pathway for the apoptosis of splenocytes in chickens.
File Format	HTM / HTML
ISSN	09603271
Issue Number	9
Volume Number	30
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2011-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Antioxidants Metabolism Chickens Diet Fluorides Toxicity Oxidative Stress Drug Effects Spleen Analysis Of Variance Animals Apoptosis Growth & Development Dose-response Relationship, Drug Endoplasmic Reticulum Blood Pharmacokinetics Glutathione Peroxidase Malondialdehyde Mitochondria Enzymology Pathology Superoxide Dismutase Time Factors Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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