NDLI: Neuroprotective effects of resveratrol derivatives from the roots of Vitis thunbergii var. sinuate against glutamate-induced neurotoxicity in primary cultured rat cortical cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chung, Ill-Min Yeo, Min-A Kim, Sun-Jin Moon, Hyung-In
Description	Country affiliation: South Korea Author Affiliation: Chung IM ( Department of Applied Life science, Kon Kuk University, Seoul, South Korea.)
Abstract	We observed that an aqueous extract of this medicinal plant exhibited significant neuroprotection against glutamate-induced toxicity in primary cultured rat cortical cells from methanol extracts of the roots of Vitis thunbergii var. sinuate (Vitaceae). To further clarify the underlying neuroprotective mechanisms of this observed effect, we isolated and identified various active fractions and components. By using such fractionation procedures, five resveratrol derivatives - vitisinols A (1), B (2), C (3), (+)-vitisin A (4), and (+)-vitisin C (5) - were isolated from the methanol extracts from the roots of V. thunbergii var. sinuate. Among these five resveratrol derivatives, 3 exhibited most significant neuroprotective activity against glutamate-induced neurotoxicity, as indicated by a cell viability of approximately 75%-85%, at concentrations ranging from 0.1 µM to 10 µM. These findings indicate that the neuroprotective effects of V. thunbergii var. sinuate might be due to the inhibition of glutamate-induced toxicity by resveratrol derivatives present in the plant.
File Format	HTM / HTML
ISSN	09603271
Issue Number	9
Volume Number	30
e-ISSN	14770903
Journal	Human & Experimental Toxicology
Language	English
Publisher	Sage Publication
Publisher Date	2011-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Toxicology Cerebral Cortex Drug Effects Glutamic Acid Toxicity Neuroglia Neurons Neuroprotective Agents Pharmacology Stilbenes Vitis Chemistry Animals Cell Culture Techniques Cell Survival Cells, Cultured Cytology Embryology Chromatography, Thin Layer Molecular Structure Pathology Isolation & Purification Plant Roots Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology

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