NDLI: Intervention of selenium on apoptosis and Fas/FasL expressions in the liver of fluoride-exposed rats.

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Intervention of selenium on apoptosis and Fas/FasL expressions in the liver of fluoride-exposed rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Miao, Keke Zhang, Lei Yang, Shuying Qian, Wei Zhang, Zigui
Description	Author Affiliation: Miao K ( College of Chemistry and Life Science, Zhejiang Normal University, Jinhua 321004, Zhejiang Province, People's Republic of China.)
Abstract	Fluorosis is a major public health problem in numerous areas around the world, including China. To alleviate this problem, selenium has been used. In this study, we aimed to investigate the influence of selenium on apoptosis in fluorosis-affected rat livers and determine the optimal selenium concentration in drinking water to fight fluorosis. The protein levels of Fas in NaF and NaF+Se (0.375 and 0.75 mg/L) groups as well as FasL in NaF, Se (0.75 and 1.5 mg/L), and NaF+Se (0.375 mg/L) groups were significantly increased compared with those in the control group. The mRNA levels of Fas in NaF and Se (1.5 mg/L) groups as well as FasL in NaF and NaF+Se (0.375 mg/L) groups were significantly increased. The protein levels of Fas in NaF+Se (1.5 mg/L) group and FasL in three NaF+Se groups were significantly decreased compared with those in the NaF group. The mRNA levels of Fas in the three NaF+Se groups and FasL in NaF+Se (0.75 and 1.5 mg/L) groups were significantly decreased. Compared with the control group, activity of GSH-Px, and SOD in the NaF group decreased obviously and MDA content increased obviously; activity of SOD in 1.5 mg/L Se group decreased obviously. Compared with the NaF group, activity of GSH-Px in NaF+Se (1.5 mg/L) group significantly increased, and MDA content decreased obviously. Thus, fluoride induced apoptosis in the liver, thereby causing liver damage in the rats. Selenium could alleviate fluorosis-induced liver injury. In particular, selenium at 1.5 mg/L is considered the optimum concentration against fluorosis.
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	36
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2013-11-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Antigens, Cd95 Biosynthesis Apoptosis Drug Effects Fas Ligand Protein Liver Metabolism Sodium Fluoride Pharmacology Sodium Selenite Animals Blotting, Western Drinking Water Fluorosis, Dental Prevention & Control Glutathione Peroxidase In Situ Nick-end Labeling Ultrastructure Male Malondialdehyde Rats Rats, Sprague-dawley Real-time Polymerase Chain Reaction Superoxide Dismutase Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

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