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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Feng, Chenchen Xie, Xiaofeng Wu, Mengjun Li, Chunzhu Gao, Man Liu, Mingxia Qi, Xinming Ren, Jin |
| Description | Country affiliation: China Author Affiliation: Feng C ( Center for Drug Safety Evaluation and Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences) |
| Abstract | Hepatic CYP1A especially CYP1A2 plays an important role in the reduction of aristolochic acid I (AAI) nephrotoxicity. In this study, we investigated the effects of tanshinone I, a strong inducer of Cyp1a, on the nephrotoxicity induced by AAI. Histopathology and blood biochemistry assays showed that tanshinone I could reduce AAI-induced acute kidney injury. Pharmacokinetics analysis revealed that tanshinone I markedly decreased AUC of AAI in plasma and the content of AAI in both liver and kidney, indicating the enhancement of AAI metabolism. Real-time PCR and Western blot analysis confirmed that tanshinone I effectively increased the mRNA and protein levels of hepatic CYP1A1 and CYP1A2 in vivo. Luciferase assay showed that tanshinone I strongly increased the transcriptional activity of CYP1A1 and CYP1A2 in the similar extent. In summary, our data suggested that tanshinone I facilitated the metabolism of AAI and prevented AAI-induced kidney injury by induction of hepatic CYP1A 1/2 in vivo. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 36 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Antineoplastic Agents, Phytogenic Pharmacology Aristolochic Acids Antagonists & Inhibitors Toxicity Carcinogens Cytochrome P-450 Cyp1a1 Biosynthesis Cytochrome P-450 Cyp1a2 Diterpenes, Abietane Kidney Diseases Chemically Induced Enzymology Animals Pharmacokinetics Area Under Curve Blood Chemical Analysis Blotting, Western Chromatography, High Pressure Liquid Metabolism Enzyme Induction Drug Effects Kidney Chemistry Pathology Liver Luciferases Male Mice Mice, Inbred C57bl Plasmids Genetics Rna Isolation & Purification Real-time Polymerase Chain Reaction Spectrophotometry, Ultraviolet Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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