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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Tabatabaei, Negar Jamalian, Jalal Owji, Ali Akbar Ramezani, Roghayeh Karbalaie, Narges Rajaeifard, Abdol Reza |
| Description | Country affiliation: Iran Author Affiliation: Tabatabaei N ( Department of Nutrition, Shiraz University of Medical Sciences, No. 23.3, Sanaee Street, Karim Khaan Zand Avenue, Tehran 1585663346, Iran. negartababai@yahoo.com) |
| Abstract | The present study compared the effects of four isocaloric diets containing (1) fresh sunflower oil not supplemented with selenium (Fresh), (2) oxidized sunflower oil not supplemented with selenium (Oxidized), (3) fresh sunflower oil supplemented with 1 ppm selenium as sodium selenite (Fresh+Se), (4) oxidized sunflower oil supplemented with 1 ppm selenium as sodium selenite (Oxidized+Se) on serum MDA concentrations, liver GPx activity and serum and liver selenium contents in growing male Sprague Dawley rats during a period of 43 days. The oxidized oil used was prepared by heating fresh sunflower oil at 180 degrees C for 48 h. Serum and liver selenium contents and liver GPx activity were significantly higher in the selenium supplemented groups compared to the non-selenium supplemented groups, but these parameters did not differ significantly between the oxidized oil fed groups and the fresh oil fed groups. Serum MDA concentrations increased significantly in the Oxidized group compared to the Fresh group. This suggests that the ingestion of oxidized oil resulted in, in vivo lipid peroxidation. Serum MDA concentrations remained significantly higher even in comparison of the Oxidized + Se group with the Oxidized group. Our results emphasize that the consumption of oxidized oil increases in vivo lipid peroxidation and thus can be deleterious to health. However, we did not observe a significant beneficial effect of selenium supplementation upon the ingestion of thermally oxidized oil on lipid peroxidation. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 11 |
| Volume Number | 46 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2008-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Food Handling Methods Glutathione Peroxidase Metabolism Liver Drug Effects Malondialdehyde Blood Plant Oils Chemistry Selenium Pharmacology Animals Dietary Supplements Hot Temperature Lipid Peroxidation Enzymology Male Oxidation-reduction Administration & Dosage Random Allocation Rats Rats, Sprague-dawley Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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