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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Paul, Avijit Das, Jayeeta Das, Sreemanti Samadder, Asmita Khuda-Bukhsh, Anisur Rahman |
| Description | Country affiliation: India Author Affiliation: Paul A ( Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani 741235, India.) |
| Abstract | This study evaluates the possible protective potentials of chelidonine and its poly lactide-co-glycolide (PLGA) encapsulated nano-form against cadmium chloride (CdCl2) induced oxidative stress and hepatotoxicity in mice, ex vivo and in vivo. Acute exposure to CdCl2 (1.0 mg/kg b.w; i.p., twice a week for 30 days) generated oxidative stress in mice through accumulation of reactive oxygen species and increased lipid peroxidation, and levels of certain liver marker enzymes (ALT, AST, ALP) with decrease in levels of GSH and certain other antioxidant enzymes (SOD, CAT, GR) in liver. Treatment with nano-chelidonine for 30 days after CdCl2 intoxication significantly reduced oxidative stress and lipid peroxidation and restored levels of GSH, cholesterol, triglyceride and antioxidant enzymes, showing ameliorative changes in histopathology of liver. Expression pattern of certain inflammatory and apoptotic signal proteins also indicated better hepato-protective abilities of nano-chelidonine, making it a more suitable protective drug than chelidonine against cadmium toxicity in mice. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 36 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Benzophenanthridines Chemistry Cadmium Chloride Antagonists & Inhibitors Toxicity Cadmium Poisoning Prevention & Control Chelidonium Drug-induced Liver Injury Drug Compounding Methods Lactic Acid Oxidative Stress Drug Effects Polyglycolic Acid Algorithms Animals Administration & Dosage Pharmacokinetics Cell Survival Pathology Excipients Hepatocytes Immunohistochemistry Indicators And Reagents Light Mice Nanoparticles Nanotechnology Particle Size Scattering, Radiation Spectrophotometry, Atomic Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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