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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Hodek, Petr Koblihová, Jitka Kizek, René Frei, Eva Arlt, Volker M. Stiborová, Marie |
| Description | Country affiliation: Czech Republic Author Affiliation: Hodek P ( Department of Biochemistry, Faculty of Science, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic.) |
| Abstract | Benzo[a]pyrene (BaP) is a human carcinogen requiring metabolic activation prior to reaction with DNA. Cytochrome P450 (CYP) 1A1 is the most important hepatic and intestinal enzyme in both BaP activation and detoxification. CYP1A2 is also capable of oxidizing BaP, but to a lesser extent. The induction of CYP1A1/2 by BaP and/or ß-naphthoflavone in liver and small intestine of rats was investigated. Both BaP and ß-naphthoflavone induced CYP1A expression and increased enzyme activities in both organs. Moreover, the induction of CYP1A enzyme activities resulted in an increase in formation of BaP-DNA adducts detected by (32)P-postlabeling in rat liver and in the distal part of small intestine in vivo. The increases in CYP1A enzyme activity were also associated with bioactivation of BaP and elevated BaP-DNA adduct levels in ex vivo incubations of microsomes of both organs with DNA and BaP. These findings indicate a stimulating effect of both compounds on BaP-induced carcinogenesis. |
| File Format | HTM / HTML |
| ISSN | 13826689 |
| Issue Number | 3 |
| Volume Number | 36 |
| e-ISSN | 18727077 |
| Journal | Environmental Toxicology and Pharmacology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Health Discipline Pharmacology Benzo(a)pyrene Toxicity Cytochrome P-450 Cyp1a1 Metabolism Dna Adducts Environmental Pollutants Animals Blotting, Western Chromatography, Thin Layer Cytochrome P-450 Cyp1a2 Biosynthesis Genetics Enzyme Activation Drug Effects Intestine, Small Enzymology Isoenzymes Liver Male Microsomes, Liver Rats Rats, Wistar Beta-naphthoflavone Pharmacology Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology |
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