NDLI: Diphenyl diselenide prevents hepatic alterations induced by paraquat in rats.

Please wait, while we are loading the content...

Year: 2017 Volume: 51

Year: 2017 Volume: 50

Year: 2017 Volume: 49

Year: 2016 Volume: 49

Year: 2016 Volume: 48

Year: 2016 Volume: 47

Year: 2016 Volume: 46

Year: 2016 Volume: 45

Year: 2016 Volume: 44

Year: 2016 Volume: 43

Year: 2016 Volume: 42

Year: 2016 Volume: 41

Year: 2015 Volume: 40

Year: 2015 Volume: 39

Year: 2014 Volume: 38

Year: 2014 Volume: 37

Year: 2013 Volume: 36

Year: 2013 Volume: 36 Issue: 3

Comparative antioxidant responses in liver of Carassius auratus exposed to phthalates: an integrated biomarker approach.

Diphenyl diselenide prevents hepatic alterations induced by paraquat in rats.

The protective effect of grape seed procyanidin extract against cadmium-induced renal oxidative damage in mice.

Evaluating the inhibitory potential of sulindac against the bleomycin-induced pulmonary fibrosis in wistar rats.

Therapeutic potential of thymoquinone against anti-tuberculosis drugs induced liver damage.

Doxorubicin mediated cardiotoxicity in rats: protective role of felodipine on cardiac indices.

Cytokine patterns in greenhouse workers occupationally exposed to -cypermethrin: an observational study.

HI-6 modulates immunization efficacy in a BALB/c mouse model.

Green synthesis of silver nanoparticles: an approach to overcome toxicity.

An in vivo insight to the toxicological profile of various organotellurides.

Evaluation of mysids and sea urchins exposed to saxitoxins.

Gestational exposure to cadmium alters crucial offspring rat brain enzyme activities: the role of cadmium-free lactation.

Ethanolic extract of Boswellia ovalifoliolata bark and leaf attenuates doxorubicin-induced cardiotoxicity in mice.

Tanshinone I protects mice from aristolochic acid I-induced kidney injury by induction of CYP1A.

Evaluation of lead levels in biological samples of mentally retarded children in different stages using advanced extraction method.

Ethyl acetate fraction of Garcina epunctata induces apoptosis in human promyelocytic cells (HL-60) through the ROS generation and G0/G1 cell cycle arrest: a bioassay-guided approach.

Effects of olive leave extract on metabolic disorders and oxidative stress induced by 2.45 GHz WIFI signals.

Jatropha curcas leaf and bark fractions protect against ultraviolet radiation-B induced DNA damage in human peripheral blood lymphocytes.

Disparity in actions of rosiglitazone against cisplatin-induced nephrotoxicity in female Sprague-Dawley rats.

Sodium arsenite and arsenic trioxide differently affect the oxidative stress, genotoxicity and apoptosis in A549 cells: an implication for the paradoxical mechanism.

Effects of oxytetracycline and amoxicillin on development and biomarkers activities of zebrafish (Danio rerio).

Intervention of selenium on apoptosis and Fas/FasL expressions in the liver of fluoride-exposed rats.

Particle-size-dependent cytokine responses and cell damage induced by silica particles and macrophages-derived mediators in endothelial cell.

Mechanisms of kidney toxicity for chromium- and arsenic-based preservatives: potential involvement of a pro-oxidative pathway.

Poly (lactide-co-glycolide) nano-encapsulation of chelidonine, an active bioingredient of greater celandine (Chelidonium majus), enhances its ameliorative potential against cadmium induced oxidative stress and hepatic injury in mice.

Effects of formaldehyde exposure on human NK cells in vitro.

Oxidative stress and apoptosis was induced by bio-insecticide spinosad in the liver of Oreochromis niloticus.

Goose fat, a promising nutrient for fish feeding, activates antioxidant enzymes in rainbow trout, Oncorhynchus mykiss.

Involvement of oxidative stress in municipal landfill leachate-induced toxicity in boar sperm.

Chlorobenzenes, lindane and dieldrin induce apoptotic alterations in human peripheral blood lymphocytes (in vitro study).

The relationship between DNA adduct formation by benzo[a]pyrene and expression of its activation enzyme cytochrome P450 1A1 in rat.

Green nanotechnology - a new hope for medical biology.

Differential influences of various arsenic compounds on antioxidant defense system in liver and kidney of rats.

Chronic toxicity of the veterinary antibiotic florfenicol to Daphnia magna assessed at two temperatures.

Mechanism of cadmium induced apoptosis in human peripheral blood lymphocytes: the role of p53, Fas and Caspase-3.

Levels and distribution of organochlorine pollutants in primary dental tissues and bone of lamb.

Microbial diversity associated with tetrodotoxin production in marine organisms.

Effect of bioactive substances found in rapeseed, raspberry and strawberry seed oils on blood lipid profile and selected parameters of oxidative status in rats.

High prevalence of CYP2D6*41 (G2988A) allele in Saudi Arabians.

Reference values of elements in human hair: a systematic review.

Impact of toxicological properties of sulfonamides on the growth of zebrafish embryos in the water.

Detrimental effects of cement mortar and fly ash mortar on asthma progression.

Antiangiogenic effects of marine sponge derived compounds on cancer.

Efficacy and safety of methimazole ointment for patients with hyperthyroidism.

Biochemical alterations induced by oral subchronic exposure to fipronil, fluoride and their combination in buffalo calves.

Tissue-specific bioconcentration of the synthetic steroid hormone medroxyprogesterone acetate in the common carp (Cyprinus carpio).

Glutamine-free condition inhibits lipopolysaccharide-induced invasion of BV2 microglial cells by suppressing of matrix metalloproteinase-9 expression.

Characterization and expression of cytochrome p450 cDNA (CYP9AT2) in Chironomus riparius fourth instar larvae exposed to multiple xenobiotics.

Exposure to the endocrine disruptor di(2-ethylhexyl)phthalate affects female reproductive features by altering pulsatile LH secretion.

Effects of perchlorate on BDE-47-induced alteration thyroid hormone and gene expression of in the hypothalamus-pituitary-thyroid axis in zebrafish larvae.

Alterations in apoptotic caspases and antioxidant enzymes in arsenic exposed rat brain regions: reversal effect of essential metals and a chelating agent.

Exposure of mayfly Ephemera orientalis (Ephemeroptera) eggs to heavy metals and discovery of biomarkers.

GS-2, a pyrazolo[1,5-a]indole derivative with inhibitory activity of topoisomerases, exerts its potent cytotoxic activity by ROS generation.

Effects of Ligustrazine on DNA damage and apoptosis induced by irradiation.

Quantification of metallothionein on the liver and kidney of rats by subchronic lead and cadmium in combination.

Protective effect of dieckol isolated from Ecklonia cava against ethanol caused damage in vitro and in zebrafish model.

Subchronic toxicity evaluation of potassium bromate in Fischer 344 rats.

Spatial distribution and toxicity of cadmium in the joint presence of sulfur in rice seedling.

Dieckol, a phlorotannin isolated from a brown seaweed, Ecklonia cava, inhibits adipogenesis through AMP-activated protein kinase (AMPK) activation in 3T3-L1 preadipocytes.

The effects of cadmium chloride and sodium selenite on protein synthesis in mouse liver.

A pilot study: the importance of inter-individual differences in inorganic arsenic metabolism for birth weight outcome.

Neurotoxicity of neem commercial formulation (Azadirachta indica A. Juss) in adult zebrafish (Danio rerio).

Oxidative stress precedes mitochondrial dysfunction in gerbil brain after aluminum ingestion.

The protective effect of melatonin and S-methylisothiourea treatments in nitrogen mustard induced lung toxicity in rats.

Sample preparation for combined chemical analysis and in vitro bioassay application in water quality assessment.

Genotoxicity and antileishmanial activity evaluation of Physalis angulata concentrated ethanolic extract.

Year: 2013 Volume: 36 Issue: 2

Year: 2013 Volume: 36 Issue: 1

Year: 2013 Volume: 35

Year: 2012 Volume: 34

Year: 2012 Volume: 33

Year: 2011 Volume: 32

Year: 2011 Volume: 31

Year: 2010 Volume: 30

Year: 2010 Volume: 29

Year: 2009 Volume: 28

Year: 2009 Volume: 27

Year: 2008 Volume: 26

Year: 2008 Volume: 25

Year: 2007 Volume: 24

Year: 2007 Volume: 23

Year: 2006 Volume: 22

Year: 2006 Volume: 21

Year: 2005 Volume: 20

Year: 2005 Volume: 19

Year: 2004 Volume: 18

Year: 2004 Volume: 17

Year: 2004 Volume: 16

Year: 2004 Volume: 15

Year: 2003 Volume: 15

Year: 2003 Volume: 14

Year: 2003 Volume: 13

Year: 1996 Volume: 2

Year: 1996 Volume: 1

Diphenyl diselenide prevents hepatic alterations induced by paraquat in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Costa, Michael D. de Freitas, Mayara L. Dalmolin, Laíza Oliveira, Lia P. Fleck, Michelli A. Pagliarini, Paula Acker, Carmine Roman, Silvane S. Brandão, Ricardo
Description	Country affiliation: Brazil Author Affiliation: Costa MD ( Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Campus UFSM, Santa Maria, RS, Brazil.)
Abstract	This study aimed to investigate the beneficial effect of diphenyl diselenide (PhSe)2 on paraquat (PQ) induced alterations in rats liver. Adult male Wistar rats received (PhSe)2 at 10 mg kg(-1), by oral administration (p.o.), during five consecutive days. Twenty-four hours after the last (PhSe)2 dose, rats received PQ at 15 mg kg(-1), in a single intraperitoneally injection (i.p.). Seventy-two hours after PQ exposure, animals were sacrificed by decapitation for blood and liver samples obtainment. Histological alterations induced by PQ exposure, such as inflammatory cells infiltration and edema, were prevented by (PhSe)2 administration. Moreover, (PhSe)2 prevented hepatic lipid peroxidation (LPO) induced by PQ and was effective in reducing the myeloperoxidase (MPO) activity in liver, which was enhanced by PQ exposure. (PhSe)2 also was effective in protecting against the reduction in ascorbic acid and non-protein thiols (NPSH) levels induced by PQ. The inhibition of glutathione S-transferase (GST) activity, in rats exposed to PQ, was normalized by (PhSe)2 pre-treatment, whereas the inhibition of catalase (CAT) activity was not prevented by (PhSe)2. The serum alkaline phosphatase (ALP) inhibition, induced by PQ administration, was also prevented by (PhSe)2 pre-treatment. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities were not modified by PQ and/or (PhSe)2 administration. Therefore, (PhSe)2 pre-treatment was effective in protecting against the hepatic alterations induced by PQ in rats. This protective effect can involve the antioxidant and anti-inflammatory properties of (PhSe)2.
File Format	HTM / HTML
ISSN	13826689
Issue Number	3
Volume Number	36
e-ISSN	18727077
Journal	Environmental Toxicology and Pharmacology
Language	English
Publisher	Elsevier
Publisher Date	2013-11-01
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Environmental Health Discipline Pharmacology Benzene Derivatives Pharmacology Drug-induced Liver Injury Pathology Prevention & Control Herbicides Antagonists & Inhibitors Toxicity Organoselenium Compounds Paraquat Animals Ascorbic Acid Metabolism Catalase Glutathione Transferase Lipid Peroxidation Drug Effects Liver Liver Function Tests Male Peroxidase Rats Rats, Wistar Sulfhydryl Compounds Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Medicine Toxicology Pharmacology

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in