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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ribeiro, Marinei Cristina Pereira Avila, Daiana Silva Schiar, Viviane Patrícia Pires Santos, Danúbia Bonfanti Dos Meinerz, Daiane F. Duarte, Marta Medeiros Frescura Monteiro, Roger Puntel, Robson de Bem, Andreza Fabro Hassan, Waseem de Vargas Barbosa, Nilda Berenice Rocha, João Batista Teixeira |
| Description | Country affiliation: Brazil Author Affiliation: Ribeiro MC ( Hospital Universitário de Santa Maria,Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil.) |
| Abstract | The study evaluated whether a diet containing diphenyl diselenide (PhSe)2, a synthetic antioxidant, could reduce the biochemical alterations induced by chronic consumption of highly enriched fructose diet and/or hydrochlorothiazide (HCTZ). Rats were fed a control diet (CT) or a high fructose diet (HFD), supplemented with or not HCTZ (4.0g/kg) and/or (PhSe)2 (3ppm) for 18weeks. HFD intake increased significantly plasma glucose, fructosamine, triglycerides and cholesterol levels. (PhSe)2 supplementation significantly reduced triglycerides and cholesterol but could not restore them to control levels. The combination of HFD and HCTZ significantly altered plasma glucose, fructosamine, triglycerides and cholesterol levels which were not restore by (PhSe)2 supplementation. Lipid peroxidation, protein carbonyl formation, vitamin C level and catalase activity decreased after HFD, HCTZ or HFD plus HCTZ ingestion. Remarkably (PhSe)2 supplementation restored the oxidative stress parameters. HCTZ decreased renal superoxide dismutase (SOD) activity, which was restored to control levels by (PhSe)2. Furthermore, the association of HFD and HCTZ decreased plasma potassium levels and aggravated HCTZ-induced hypomagnesemia and hypertriglyceridemia. Here we provided evidence of the involvement of oxidative stress and metabolic disorders in a rat model of HFD associated or not with HTCZ. (PhSe)2 supplementation reduced the oxidative stress and this compound should be considered for the treatment of biochemical disturbances and oxidative stress in other animal models of metabolic disorders. |
| File Format | HTM / HTML |
| ISSN | 00092797 |
| Issue Number | 3 |
| Volume Number | 204 |
| e-ISSN | 18727786 |
| Journal | Chemico-Biological Interactions |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-08-25 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry Discipline Pharmacology Antioxidants Pharmacology Benzene Derivatives Diet Dietary Supplements Fructose Metabolism Hydrochlorothiazide Organoselenium Compounds Oxidative Stress Drug Effects Animals Catalase Down-regulation Male Rats Rats, Wistar Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology |
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